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Regulation of somatotroph differentiation and growth hormone (GH) secretion by corticosterone and GH-releasing hormone during embryonic development

Dean, C.E.; Porter, T.E.

Endocrinology 140(3): 1104-1110

1999


ISSN/ISBN: 0013-7227
PMID: 10067832
DOI: 10.1210/endo.140.3.6586
Accession: 011270531

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The role of extracellular factors in the regulation of anterior pituitary cell differentiation and GH secretion during embryonic development was investigated. Previously, we reported that somatotrophs become a significant population by embryonic day (e-) 16 of the chick and that corticosterone is the active compound responsible for the observed GH cell-differentiating activity of e-16 serum.

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