+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Relationships of allergic sensitization, total immunoglobulin E and blood eosinophils to asthma severity in children of the EGEA Study



Relationships of allergic sensitization, total immunoglobulin E and blood eosinophils to asthma severity in children of the EGEA Study



Clinical and Experimental Allergy 33(6): 746-751



Background Although allergy is highly associated with childhood asthma, it is not well known if there is a relationship between the intensity of allergic sensitization and asthma severity. Objective The objectives of the study were to examine the relationships between several markers of allergy and asthma severity in asthmatic children included in the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyper-responsiveness and atopy (EGEA). Methods The population comprised 216 asthmatic children below 16 years of age. Total IgE and blood eosinophil counts were measured and skin prick tests to 11 aeroallergens were performed. The intensity of the allergic sensitization was assessed by the number of positive skin prick tests and by skin weal sizes. Asthma severity was measured with four criteria: a clinical severity score, history of hospitalization for asthma, FEV1% predicted and inhaled steroid use in the last 12 months. Results Most of the children were sensitized to at least one aeroallergen (88.2%). Atopy was not related to the severity of asthma, except for a tendency for a more severe clinical score in non-atopic children. The type and intensity of the allergic sensitization were not associated with any criteria of asthma severity. Total IgE was significantly increased in children treated with inhaled corticosteroids and in children ever hospitalized for asthma (P-values 0.009 and 0.04, respectively). Eosinophil counts were not related to asthma severity. Conclusion Our results suggest that severe childhood asthma may be related to a high level of total IgE but not to blood eosinophil counts. The lack of positive relationships between both atopy and the intensity of allergic sensitization with asthma severity supports the hypothesis of different risk factors being associated with asthma and with the severity of asthma.

(PDF emailed within 0-6 h: $19.90)

Accession: 011277914

Download citation: RISBibTeXText

PMID: 12801307

DOI: 10.1046/j.1365-2222.2003.01674.x


Related references

Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma. European Respiratory Journal 15(3): 470-477, 2000

Relationships of active smoking to asthma and asthma severity in the EGEA study. European Respiratory Journal 15(3): 470-477, March, 2000

Relationships of various variables to assess asthma severity in children in EGEA Preliminary results. European Respiratory Journal Supplement 10(25): 144S, Sept, 1997

Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma. Journal of International Medical Research 39(6): 2209-2216, 2012

Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development. Journal of Allergy and Clinical Immunology (): -, 2016

Relationships of active and passive smoking to total IgE in adults of the Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). American Journal of Respiratory and Critical Care Medicine 161(4 Pt 1): 1241-1246, 2000

Association of serum eosinophilia and total immunoglobulin E concentration with the risk of allergic symptoms and allergic sensitization, respectively: A 2-year follow-up study. International Journal of Pediatric Otorhinolaryngology 86(): 167-171, 2016

Scores of asthma and asthma severity reveal new regions of linkage in EGEA study families. European Respiratory Journal 30(2): 253-259, 2007

Total serum IgE and its association with asthma symptoms and allergic sensitization among children. Journal of Allergy & Clinical Immunology 104(1): 28-36, July, 1999

Multidimensional character of asthma severity in the EGEA study. Revue des Maladies Respiratoires 21(5 Pt 1): 917-924, 2004

Familial resemblance of asthma severity in the EGEA* study. American Journal of Respiratory and Critical Care Medicine 165(2): 185-189, 2002

The relationship of blood lead with immunoglobulin E, eosinophils, and asthma among children: NHANES 2005-2006. International Journal of Hygiene and Environmental Health 217(2-3): 196-204, 2014

Environmental factors for asthma severity and allergy: results from the EGEA study. Revue des Maladies Respiratoires 24(5): 599-608, 2007

Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Journal of Asthma 49(4): 423-433, 2012