EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Replication of clinical measles virus strains in hispid cotton rats


Replication of clinical measles virus strains in hispid cotton rats



Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 221(1): 53-62



ISSN/ISBN: 0037-9727

PMID: 10320632

DOI: 10.1046/j.1525-1373.1999.d01-54.x

An alternative model to nonhuman primates to study measles virus (MV) pathogenesis, to evaluate potential MV vaccines, or to screen for potential antivirals effective against this virus is highly desirable. The laboratory-adapted Edmonston strain of MV has been reported to replicate in the lungs of hispid cotton rats following intranasal inoculation, immunosuppress infected animals, and disseminate widely from the lungs, making these animals a candidate model. However, clinical MV strains have generally not been found to grow in these animals, limiting the utility and acceptance of this model. In the present studies we demonstrate reproducible replication of several clinical MV strains in hispid cotton rats. As with the Edmonston strain, leukocytes appear to be the primary target cells of these viruses following intranasal inoculation, and extrapulmonary dissemination is common. It is also demonstrated that prior MV infection or immunization of test animals with MV vaccine prevents pulmonary tract infection. These findings should make the MV-cotton rat model more acceptable.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011284613

Download citation: RISBibTeXText

Related references

Measles virus replication in lungs of hispid cotton rats after intranasal inoculation. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 201(1): 80-87, 1992

Measles Virus Replication in Lungs of Hispid Cotton Rats after Intranasal Inoculation. Experimental Biology and Medicine 201(1): 80-87, 1992

Dry powder measles vaccine: particle deposition, virus replication, and immune response in cotton rats following inhalation. Vaccine 29(5): 905-912, 2011

Pathology of Black Creek Canal virus infection in juvenile hispid cotton rats (Sigmodon hispidus). Vector Borne and Zoonotic Diseases 10(6): 621-628, 2010

Attenuated Salmonella enterica serovar Typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats. Journal of Virology 77(9): 5209-5217, 2003

Role of interferon in replication of virulent and attenuated strains of measles virus. Journal of General Virology 4(4): 513-522, 1969

Plaque Differentiation and Replication of Virulent and Attenuated Strains of Measles Virus. Journal of Bacteriology 88: 1448-1458, 1964

Faster replication and higher expression levels of viral glycoproteins give the vesicular stomatitis virus/measles virus hybrid VSV-FH a growth advantage over measles virus. Journal of Virology 88(15): 8332-8339, 2014

Altered virulence of vaccine strains of measles virus after prolonged replication in human tissue. Journal of Virology 73(10): 8791-8797, 1999

Viral replication and development of specific immunity in macaques after infection with different measles virus strains. Journal of Infectious Diseases 170(2): 443-448, 1994

Activity of polymerase proteins of vaccine and wild-type measles virus strains in a minigenome replication assay. Journal of Virology 76(14): 7073-7081, 2002

Variations on hemagglutinin gene of Zhejiang measles virus strains and differences with measles strains circulated both at home and abroad. Zhonghua Yu Fang Yi Xue Za Zhi 47(7): 616-621, 2013

Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. Journal of Infectious Diseases 196(12): 1784-1793, 2007

Recombinant measles viruses expressing respiratory syncytial virus proteins induced virus-specific CTL responses in cotton rats. Vaccine 32(35): 4529-4536, 2014

Sindbis virus-based measles DNA vaccines protect cotton rats against respiratory measles: relevance of antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and Th1-type cytokines as correlates of immunity. Journal of Virology 83(6): 2789-2794, 2009