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Sarcoplasmic reticulum Ca(2+) atpase (SERCA) 1a structurally substitutes for SERCA2a in the cardiac sarcoplasmic reticulum and increases cardiac Ca(2+) handling capacity



Sarcoplasmic reticulum Ca(2+) atpase (SERCA) 1a structurally substitutes for SERCA2a in the cardiac sarcoplasmic reticulum and increases cardiac Ca(2+) handling capacity



Circulation Research 89(2): 160-167



Ectopic expression of the sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA) 1a pump in the mouse heart results in a 2.5-fold increase in total SERCA pump level. SERCA1a hearts show increased rates of contraction/relaxation and enhanced Ca2+ transients; however, the cellular mechanisms underlying altered Ca2+ handling in SERCA1a transgenic (TG) hearts are unknown.

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Accession: 011324473

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PMID: 11463723

DOI: 10.1161/hh1401.093584


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