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Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: Replacement of the sialic acid moiety



Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: Replacement of the sialic acid moiety



Bioorganic & Medicinal Chemistry Letters 10(19): 2197-2200, 2 October



In a program directed towards the design and synthesis of mimics of ganglioside GM1, the NeuAc recognition domain was replaced by simple hydroxy acids, and the affinity of the new ligands to the cholera toxin was determined by fluorescence spectroscopy. The (R)-lactic acid derivative 4 was found to display the highest affinity of the series (KD = 190 microM).

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Accession: 011331676

Download citation: RISBibTeXText

PMID: 11012028

DOI: 10.1016/s0960-894x(00)00428-5


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