+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Segregation of working memory functions within the dorsolateral prefrontal cortex



Segregation of working memory functions within the dorsolateral prefrontal cortex



Experimental Brain Research 133(1): 23-32



It is now widely accepted that the prefrontal cortex (PFC) plays a critical role in the neural network subserving working memory (WM). At least three related questions are still under debate: (1) is the PFC critical for all constituent processes of WM (i.e., short-term storage, manipulation, and utilization of mental representations) or only in one or a few of them? (2) Is there segregation of function among different cytoarchitectonic subdivisions of the PFC? (3) If this be the case, is this segregation based on the nature of the information being processed or on the type of cognitive operation performed? The present review article describes findings in the monkey supporting a modular "domain-specific" model of PFC functional organization with respect to WM operations. In this model, the dorsolateral prefrontal cortex (DLPFC) is composed of several subregions, based primarily on the nature of the information being processed in WM. Storage and processing functions are integrally related in each area. Future studies designed to map as yet uncharted areas of prefrontal cortex with refined anatomical and physiological approaches may provide a critical test of the model and evaluate the extent to which it applies generally or, instead, mainly to visual domains or only to dorsolateral convexity areas.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011334459

Download citation: RISBibTeXText

PMID: 10933207

DOI: 10.1007/s002210000397


Related references

Segregation of working memory functions in prefrontal cortex in primates. Society for Neuroscience Abstracts 23(1-2): 501, 1997

Working memory and the mid-dorsolateral prefrontal cortex. Society for Neuroscience Abstracts 24(1-2): 18, 1998

Dorsolateral prefrontal cortex dysfunction in schizophrenia relationship to both working memory and long-term memory. Society for Neuroscience Abstracts 26(1-2): Abstract No -112 13, 2000

The role of the mid-dorsolateral prefrontal cortex in working memory. Experimental Brain Research 133(1): 44-54, 2000

Dorsolateral prefrontal cortex and verbal working memory. Society for Neuroscience Abstracts 23(1-2): 2110, 1997

Dorsolateral prefrontal cortex promotes long-term memory formation through its role in working memory organization. Journal of Neuroscience 26(3): 916-925, 2006

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques. Neuroscience Bulletin 29(3): 381-389, 2013

Human Dorsolateral Prefrontal Cortex Is Not Necessary for Spatial Working Memory. Journal of Neuroscience 36(10): 2847-2856, 2016

The roles of the dorsolateral prefrontal cortex and hippocampus in working memory and schizophrenia. Biological Psychiatry 35(9): 622, 1994

Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophrenia Research 108(1-3): 143-150, 2009

Dorsolateral prefrontal cortex, working memory, and prospective coding for action. Journal of Neuroscience 27(8): 1801-1802, 2007

The role of mid-dorsolateral prefrontal cortex in working memory: a connectionist model. Neurocomputing 44-46: 1009-1016, 2002

Molecular influences on working memory circuits in dorsolateral prefrontal cortex. Progress in Molecular Biology and Translational Science 122: 211-231, 2014

Anodal transcranial direct current stimulation of the right dorsolateral prefrontal cortex enhances memory-guided responses in a visuospatial working memory task. Functional Neurology 29(3): 189-193, 2015

Dorsolateral prefrontal cortex contributions to working memory and inhibition as revealed by fMRI. Society for Neuroscience Abstracts 24(1-2): 1252, 1998