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Selective in vitro and in vivo binding of (125I)ADAM to serotonin transporters in rat brain



Selective in vitro and in vivo binding of (125I)ADAM to serotonin transporters in rat brain



Synapse (New York) 38(4): 403-412



An improved iodinated tracer, ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine) for imaging serotonin transporters (SERT) with single photon emission computerized tomography (SPECT), was prepared and characterized. Scatchard analysis of saturation binding of (125I)ADAM to rat frontal cortical membrane homogenates gave a Kd value of 0.15 +- 0.03 nM and a Bmax value of 194 +- 65 fmol/mg protein.

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