+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a, GT1b and GM3

Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a, GT1b and GM3

Journal of the Neurological Sciences 188(1-2): 9-11

We report a patient with sensorimotor demyelinating neuropathy with high-titer IgM antibody against gangliosides GD1a, GT1b and GM3. The patient was a 65-year-old male who was hospitalized with chief complaints of muscular weakness of all limbs and numbness of the hands and feet. Nerve-conduction studies revealed reduced conduction velocities of the motor nerves with increased temporal dispersion and loss of sensory nerve action potentials. Treatment with steroids was ineffective. IgM antibody against GD1a, GT1b and GM3, which are known to be the ligands for myelin-associated glycoprotein (MAG), might have played a role in the demyelination in this patient by inhibiting adhesion between myelin and axonal membrane.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 011341483

Download citation: RISBibTeXText

PMID: 11489278

DOI: 10.1016/s0022-510x(01)00537-8

Related references

IgM antibodies to GD1b, GT1b and GD3 and IgG antibodies to GD1a in two patients with chronic sensory demyelinating neuropathy. Journal of Neuroimmunology 90(1): 87, 1998

A case of chronic inflammatory demyelinating neuropathy associated with antibodies to gangliosides GM1 and GalNAc-GD1a. Rinsho Shinkeigaku 37(3): 228-232, 1997

Biosynthesis of the major brain gangliosides GD1a and GT1b. Glycobiology 22(10): 1289-1301, 2012

Synaptotagmin associated with gangliosides GT1b/GD1a is a receptor for botulinum type B neurotoxin. Journal of Neurochemistry 65(Suppl. ): S11, 1995

Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. Cell Biochemistry and Function 18(1): 41-45, 2000

Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B. Cell Proliferation 35(2): 105-115, 2002

Assignment of the carbon-13 nuclear magnetic resonance spectra of gangliosides GM4, GM3, GM2, GM1, GD1a, GD1b, and GT1b. Biochemistry 21(6): 1260-1271, 1982

Modulation of neuraminidase activity by the physical state of phospholipid bilayers containing gangliosides Gd1a and Gt1b. Biochemistry 23(7): 1442-1448, 1984

Serum IgM binding to gangliosides GalNAc-GD1a and GM2 Association with a chronic demyelinating sensory motor polyneuropathy. Neurology 54(7 Supp 3): A369, 2000

Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy. Journal of Neuroscience 25(7): 1620-1628, 2005

Anti-GD1a and anti-GT1b IgM antibody response as predictors of survival in soft tissue sarcoma. Proceedings of the American Association for Cancer Research Annual Meeting 42: 739-740, 2001

Acute pure motor demyelinating neuropathy with hyperreflexia and anti-GalNAc-GD1a antibodies. Clinical Neurology and Neurosurgery 114(10): 1345-1347, 2012