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Simultaneous determination of medroxyprogesterone acetate and estradiol valerate by first derivative UV spectrophotometry



Simultaneous determination of medroxyprogesterone acetate and estradiol valerate by first derivative UV spectrophotometry



Journal of Faculty of Pharmacy of Gazi University 16(2): 69-76



Binary combinations of medroxyprogesterone acetate (MA) and estradiol valerate (EV) were determined by first derivative UV spectrophotometry. First derivative absorbance-values at 247.5 nm (For MA) and 275.0 nm and 292.0 nm (For EV) were read against blank. Solutions of standards between 5-25 mug/ml and 20-140 mug/ml for MA and EV respectively were prepared in methanol. The recoveries of the drugs from standard mixtures were between 99.7 % and 99.9 %. The precision of the methods for MA and EV were 1.31 % and 1.51 as % relative standard deviation, respectively.

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Accession: 011362643

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