+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sleep abnormalities in mentally retarded autistic subjects: Down's syndrome with mental retardation and normal subjects



Sleep abnormalities in mentally retarded autistic subjects: Down's syndrome with mental retardation and normal subjects



Brain & Development 21(8): 548-553



We compared sleep parameters in mentally retarded infantile autism (MRIA) and mentally retarded Down's syndrome (MRDS) by means of polysomnography, evaluating traditional analysis with particular attention to the phasic components in each disorder. Data were compared with those obtained in normal subjects matched for age and sex. Mental age, Intellectual Quotient and the Childhood Autism Rating Scale were performed to obtain an estimation of the neuropsychological deficit. Abnormalities of phasic components of sleep and the presence of REM sleep components into non-REM sleep were observed in both MRIA and MRDS even if in different ways. In fact, MRDS subjects presented a reduction of REM sleep percentage and R index (number of high frequency REMs against number of low frequency REMs) and this was positively correlated to a low IQ. Unlike MRDS subjects, MRIA subjects did not show any parallelism between intellectual abilities and REM sleep deficit. In addition, the presence of undifferentiated sleep in autistic subjects implies a maturational deficit that is still present in adulthood. Finally, a high R index in MRIA was observed. This finding, which is not present in MRDS, could represent an estimation of the disorganized arrival of information caused by a dyscontrol or a reduction of inhibitor pathway. With reference to sleep mechanisms, our results suggest that the cognitive deficit in MRIA may differ from that of MRDS subjects. A maturational deficit of CNS with a dysfunction of brainstem monoaminergic neurons could represent the underlying mechanism.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011368001

Download citation: RISBibTeXText

PMID: 10598057

DOI: 10.1016/s0387-7604(99)00077-7


Related references

High occurrence of Brachydactyly-Mental Retardation syndrome among mentally retarded subjects in Italy. European Journal of Human Genetics 10(Suppl. 1): 221, 2002

A preliminary comparison of phonological development in autistic, normal, and mentally retarded subjects. British Journal of Disorders of Communication 12(2): 137-147, 1977

L-dopa and REM sleep in normal and mentally retarded subjects. Biological Psychiatry 6(3): 295-299, 1973

The palmo-mental reflex in normal and mentally retarded subjects. Developmental Medicine and Child Neurology 16(1): 59-63, 1974

Phonological investigation of verbal autistic and mentally retarded subjects. Journal of Autism and Childhood Schizophrenia 6(4): 303-316, 1976

Ovalocytosis in normal and mentally retarded subjects. American Journal of Mental Deficiency 70(4): 515-519, 1966

A possible locus for X-linked non-specific mental retardation identified in two subjects with androgen insensitivity syndrome and mental retardation. European Journal of Human Genetics 4(Suppl. 1): 91, 1996

Possible risk factors and signs of mental retardation comparative study of mentally retarded and normal children. Kurume Medical Journal 31(4): 301-308, 1985

Possible risk factors and signs of mental retardation (MR)--comparative study of mentally retarded and normal children. Kurume Medical Journal 31(4): 301-307, 1984

A comparison of the distractibility of intellectually normal and mentally retarded subjects. Dissertation Absts: 1719, 1956

Intelligence and inspection time in normal and mentally retarded subjects. British Journal of Psychology 74: 365-370, 1983

Hypothesis-testing from a limited set: an example of mentally retarded subjects outperforming college subjects. American Journal of Mental Deficiency 79(6): 736-738, 1975

On the nosology of moderate mental retardation with special attention to X-linked mental retardation. A diagnostic genetic survey of 274 institutionalized moderately mentally retarded men. Genetic Counseling 1(1): 47-56, 1990

Orientating responses of mentally retarded and normal subjects to word-signals. British Journal of Psychology 62(1): 89-96, 1971

Resumption of interrupted tasks by normal and educable mentally retarded subjects. American Journal of Mental Deficiency 73(4): 657-660, 1969