+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Sleep structure and sleep-wake rhythm in elderly patients with dementia

Sleep structure and sleep-wake rhythm in elderly patients with dementia

Journal of Saitama Medical School 28(3): 131-137, July

Sleep structure in dementia is influenced by various factors, including the underlying cause and severity of dementia, the presence of somatic complications, the level of activities of daily living (ADL) and the patient's age. The characteristics of sleep structure and the sleep-wake rhythm in elderly dementia patients, eleven bedridden patients and nine semi-dependents assessed by clinical dementia rating (CDR) were studied by comparing their night sleep polygraphs and records of day and night activity levels with those of normal elderly group. To examine the effect of social interactions on nocturnal sleep, activity levels were recorded for the twelve bedridden patients over a period of four consecutive days. In dementia groups (N=20), the percentages of stage I sleep was significantly higher (P<0.01) and the percentages of stage II sleep, slow wave sleep and sleep efficiency index were significantly lower (P<0.01) than that in normal healthy elderly groups (N=10). In the bedridden groups (N=11), the percentages of stage II sleep and REM sleep were significantly lower (P<0.01) and the percentages of stage I sleep was significantly higher (P<0.01) than that in semi-dependent groups (N=9). Furthermore, DA (the daytime activity) and %DA (ratio of daytime activity to nighttime activity) decreased significantly in the dementia groups than normal healthy elderly groups and only a few cases in dementia groups showed a clear circadian rhythm of activity/rest. Also, the sleep rate during nighttime for the bedridden patients (N=12) increased following social interactions. In particular, the sleep rate of patients who had a sleep rate of less than 40% for a standard night increased significantly after social and interactive exercises (P<0.01). The observed changes in sleep structure and loss of circadian rhythm of activity/rest recognized in elderly dementia suggest the possibility of the dysfunction of a biological rhythm caused by functional and physiological changes in the brain. Moreover, manipulation of social and interactive exercises is a useful therapeutic method for the improvement of sleep disorder in bedridden patients deficient in social synchronizers who sleep poorly at night.

(PDF emailed within 1 workday: $29.90)

Accession: 011368363

Download citation: RISBibTeXText

Related references

Sleep wake rhythm disorder and phototherapy in elderly patients with dementia. Racagni, G , N Brunello And T Fukuda (Ed ) International Congress Series, No 968 Biological Psychiatry, Vols 1 And 2; Proceedings Of The 5th World Congress Of Biological Psychiatry, Florence, Italy, June 9-14, Xxviii+886p (Vol 1); Xxxi+949p (Vol 2) Elsevier Science Publishers B V : Amsterdam, Netherlands; (Dist in The Usa And Canada By Elsevier Science Publishing Co , Inc : New York, New York, Usa) Illus 837-840, 1991

Sleep wake rhythm disorders and phototherapy treatment in elderly patients with dementia. Electroencephalography & Clinical Neurophysiology 75(1): S109, 1990

Personality differences in patients with delayed sleep-wake phase disorder and non-24-h sleep-wake rhythm disorder relative to healthy sleepers. Sleep Medicine 30: 128-135, 2017

Circadian Melatonin and Temperature Taus in Delayed Sleep-wake Phase Disorder and Non-24-hour Sleep-wake Rhythm Disorder Patients: An Ultradian Constant Routine Study. Journal of Biological Rhythms 31(4): 387-405, 2016

Circadian rhythm sleep disorders: Part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. Sleep (Rochester) 30(11): 1484-1501, 2007

Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome. Sleep Medicine Reviews 11(6): 485-496, 2007

Assessing the best algorithm for sleep wake rhythm by actimetric data in sleep apnea- and narcolepsy-patients. Journal of Sleep Research 7(SUPPL 2): 281, Sept, 1998

Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep-wake rhythm disorders. Journal of Pineal Research 25(4): 201-210, 1999

Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep-wake rhythm disorders. Journal of Pineal Research 25(4): 201-210, 1998

Effects of periodic bright light and forced sleep-wake schedule on the circadian cortisol rhythm in a non-24 hour sleep-wake subject who lacks nocturnal melatonin rise. Japanese Journal of Physiology 45(SUPPL 1): S216, 1995

A multicenter study of sleep-wake rhythm disorders: Clinical features of sleep-wake rhythm disorders. Psychiatry and Clinical Neurosciences 50(4): 195-201, 1996

Circadian Rhythm Sleep Disorder: Irregular Sleep Wake Rhythm Type. Sleep Medicine Clinics 4(2): 213-218, 2010

Predictors of circadian sleep-wake rhythm maintenance in elders with dementia. Aging & Mental Health 8(2): 143-152, 2004

Changes in the sleep-wake rhythm, sleep quality, mood, and quality of life of patients receiving treatment for lung cancer: A longitudinal study. Chronobiology International 34(4): 451-461, 2017

Light therapy can restore a disturbed sleep/wake rhythm in dementia: but what is the basis of its efficacy?. Tijdschrift Voor Gerontologie en Geriatrie 26(6): 264-269, 1995