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Slow proliferation as a survival advantage: an attempt to resolve a paradox



Slow proliferation as a survival advantage: an attempt to resolve a paradox



Journal of Theoretical Biology 210(3): 319-325



A model is proposed for immunological high zone- and self-tolerance that is based on the concept of overstimulation of replication: It is demonstrated that if proliferation is hindered by delayed response to nutritional deficiency, then under competitive conditions slower proliferation can become a survival advantage. This offers a resolution of the paradox that self-antigens promote both positive and negative selection in the development of lymphocytes. It also suggests that maintaining nutrition and caloric intake at a minimal level can prolong the survival of cancer patients if the cancer cells replicate more rapidly than healthy ones.

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Accession: 011368747

Download citation: RISBibTeXText

PMID: 11397132

DOI: 10.1006/jtbi.2001.2308


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