Solid-phase synthesis: A linker for side-chain anchoring of arginine
Garcia, O.; Nicolas, E.; Albericio, F.
Tetrahedron Letters 44(28): 5319-5321, 7 July
2003
ISSN/ISBN: 0040-4039 DOI: 10.1016/s0040-4039(03)01203-6
Accession: 011374446
A new linker based on a chroman system is described for the side-chain anchoring of Arg and other guanidine-containing molecules. The system is compatible with the Fmoc/t Bu solid-phase strategy, because the release of the final product is achieved by treatment with TFA in the presence of scavengers.
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