+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Study on polyol metabolism in children with insulin dependent diabetes mellitus: Clinical significance of plasma 1,5-anhydroglucitol levels in children with insulin dependent diabetes mellitus

Study on polyol metabolism in children with insulin dependent diabetes mellitus: Clinical significance of plasma 1,5-anhydroglucitol levels in children with insulin dependent diabetes mellitus

Medical Journal of Hiroshima University 46(3-4): 99-106

Recently plasma 1,5-anhydroglucitol (AG) level has been reported to be useful for diabetes screening and glycemic control in non-insulin dependent diabetes mellitus. However, its clinical significance has not been fully evaluated in children with insulin dependent diabetes mellitus (IDDM). The plasma levels of AG and HbA1c were measured in 28 IDDM outpatients (12 boys, 16 girls, 15.9 +- 6.6 years). The plasma AG concentration (pAG) was determined by gas chromatography. pAG in IDDM patients (2.0 +- 4.1 mug/ml) was significantly lower (p<0.01) than in healthy subjects (23.5 +- 6.5 mug/ml). The pAG was significantly higher (p<0.01) in 5 newly diagnosed diabetic patients than in diabetic patients with over 3 years' duration. The recovery of pAG by over 10 mug/ml was recognized after starting insulin treatment in 3 newly diagnosed diabetic patients. On the other hand, it remained under 5.0 mug/ml (most of them, 3.0 mug/ml) in IDDM with over 3 years' duration. pAG was significantly different among the patients with over 3 years. duration with similar HbA1c levels. These observation suggest that it is difficult to use as a clinical marker for glycemic control in long standing IDDM. Although further studies are needed to clarify whether augmentation of glucose oscillation, in long standing IDDM patients with fair glycemic control, may give rise to the discrepancy between AG and HbA1c.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 011418344

Download citation: RISBibTeXText

Related references

Fasting and postprandial plasma glucose and peripheral insulin levels in insulin-dependent diabetes mellitus and non-insulin-dependent diabetes mellitus subjects during continuous intraperitoneal versus subcutaneous insulin delivery. Transplantation Proceedings 27(6): 3329-3330, 1995

A genetic study of epistasis between genotypes responsible for juvenile onset type diabetes mellitus insulin dependent diabetes mellitus and hla 2. the assumption of dominance of insulin dependent diabetes mellitus. Journal of the Japan Diabetes Society 27(11): 1147-1156, 1984

Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus. European Journal of Endocrinology 136(2): 173-179, 1997

Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus. Annals of the New York Academy of Sciences 958: 232-234, 2002

Human sciatic nerve phospholipid profiles from non-diabetes mellitus, non-insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus individuals. A 31P NMR spectroscopy study. International Journal of Biochemistry 26(6): 759-767, 1994

Plasma and erythrocyte vitamin E levels in children with insulin dependent diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism 12(2): 193-196, 1999

Myocardial mRNA expression of insulin-dependent transmembrane glucose transporter is increased in human insulin-dependent diabetes mellitus and decreased in non-insulin-dependent diabetes mellitus. European Heart Journal 20(ABSTR SUPPL ): 207, 1999

High prevalence of low plasma IGF-1 levels in children and adolescents with insulin dependent diabetes mellitus. Pediatric Research 33(5 SUPPL ): S76, 1993

Clinical significance of urinary C-peptide excretion in children with insulin-dependent diabetes mellitus. Acta Paediatrica Scandinavica 78(2): 271-277, 1989

Plasma free amino acid levels and their clinical significance in patients with non insulin dependent diabetes mellitus. Journal of the Japan Diabetes Society 30(6): 511-517, 1987

Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls. European Journal of Immunogenetics 22(6): 443-465, 1995

Modified glucagon test allowing simultaneous estimation of insulin secretion and insulin sensitivity: application to obesity, insulin-dependent diabetes mellitus, and noninsulin-dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 80(2): 393-399, 1995

Clinical characteristics inheritance of diabetes mellitus and insulin secretion in the non insulin dependent diabetes mellitus subgroup called maturity onset diabetes in the young. Diabetes Research & Clinical Practice (SUPPL 1): S146, 1985

Circulating glucagon antibodies in children who have insulin-dependent diabetes mellitus. Clinical significance and characterization. Diabetes 28(4): 294-299, 1979

Variations of 1-deoxyglucose(1,5-anhydroglucitol) content in plasma from patients with insulin-dependent diabetes mellitus. Clinical Chemistry 29(7): 1396-1398, 1983