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Synthesis and biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods



Synthesis and biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods



Bioorganic & Medicinal Chemistry Letters 13(6): 1141-1145, 24 March



New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.

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Accession: 011439684

Download citation: RISBibTeXText

PMID: 12643930

DOI: 10.1016/s0960-894x(03)00033-7


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