+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Synthesis of carbon-14 labeled (R)-3-fluoro-4-(2'-(5'', 6'', 7'', 8''-tetrahydro-5'', 5'', 8'', 8''-tetramethyl-2''-naphthyl)-(2'-hydroxy-14C))(carbonyl-14C)acetamidobenzoic acid



Synthesis of carbon-14 labeled (R)-3-fluoro-4-(2'-(5'', 6'', 7'', 8''-tetrahydro-5'', 5'', 8'', 8''-tetramethyl-2''-naphthyl)-(2'-hydroxy-14C))(carbonyl-14C)acetamidobenzoic acid



Journal of Labelled Compounds and Radiopharmaceuticals 46(2): 159-165



Carbon-14 labeled (R)-3-fluoro-4-(2'-(5'', 6'', 7'', 8''-tetrahydro-5'', 5'', 8'', 8''-tetramethyl-2''-naphthyl)-(2'-hydroxy-14C))(carbonyl-14C)acetamidobenzoic acid, 1, was prepared in a six step radioactive synthesis from diethyl (carboxylate-14C1,2) oxalate. The penultimate compound was purified by chiral HPLC, which following deprotection yielded 1 in an overall radiochemical yield of 6.8%.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 011443474

Download citation: RISBibTeXText


Related references

Synthesis of 7 4' fluoro 3 3' 5 trimethyl 1 1' biphenyl 2 yl 3 hydroxy 5 oxo 5 carbon 13 heptanoic acid and trans 6 2 4' fluoro 3 3' 5 trimethyl 1 1' biphenyl 2 ylethyl 3 4 5 6 tetrahydro 6 carbon 13 4 hydroxy 2h pyran 2 one. Journal of Labelled Compounds and Radiopharmaceuticals 24(7): 839-850, 1987

Synthesis of naphthaline derivatives analogous to 5 hydroxy tryptophan 5 hydroxy tryptamine and 5 hydroxy iaa beta hydroxy naphthyl 1 alanine beta hydroxy naphthyl 1 ethylamine and 7 hydroxy naphthyl 1 acetic acid. Zeitschrift fuer Klinische Chemie und Klinische Biochemie 10(4): 179-180, 1972

Synthesis of a new class of retinoid tritium labeled e 4 2 5 6 7 8 tetrahydro 5 5 8 8 tetramethyl 2 naphthalenyl 1 propenylbenzoic acid with a high specific activity. Journal of Labelled Compounds & Radiopharmaceuticals 22(8): 843-850, 1985

Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. Journal of Medicinal Chemistry 26(11): 1653-1656, 1983

Synthesis of carbon 14 labeled anti bacterial agent synthesis of carbon 14 labeled 1 ethyl 6 fluoro 1 4 dihydro 4 oxo 7 1 piperazinyl 3 quinoline carboxylic acid. Journal of Labelled Compounds & Radiopharmaceuticals 18(12): 1765-1772, 1981

Studies in anti fertility agents part 10 seco steroids part 4 synthesis of 2 methyl 2 2 6 hydroxy 1 2 3 4 tetrahydro 1 naphthyl ethyl cyclo pentan 1 one and 2 methyl 2 2 6 hydroxy 1 2 3 4 tetrahydro 1 naphthyl ethyl cyclo pentan 1 ol. Indian Journal of Chemistry 11(10): 1054-1055, 1973

Pharmaceutical uses of substituted 6 5 6 7 8 tetrahydro 5 5 8 8 tetramethyl 2 naphthyl 2 naphthoic acid and its esters us patent 4666941 may 19 1987. 1987

Synthesis of the 5-hydroxytryptophan-, 5-hydroxytryptamine- and 5-hydroxyacetic acid-analogs beta-[7-[hydroxy-naphthyl-(1)]-alanine, beta-[7-hydroxy-naphthyl-(1)]-ethylamine and [7-hydroxy-naphthl-(1)]-acetic acid. Zeitschrift für Klinische Chemie und Klinische Biochemie 10(4): 179-180, 1972

Biotransformation of a new synthetic retinoid, 4-(5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl) benzoic acid (Am-80), in the rat: Structure elucidation of the metabolites by mass and nmr spectrometry. Xenobiotica 24(12): 1177-1193, 1994

Biotransformation of a new synthetic retinoid, 4-[(5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl] benzoic acid (Am-80), in the rat. Structure elucidation of the metabolites by mass and nmr spectrometry. Xenobiotica; the Fate of Foreign Compounds in Biological Systems 24(12): 1177-1193, 1994

Synthesis of carbon 14 labeled racemic trans 6 4 4 bis 4 fluorophenyl 3 1 methyl 1h tetrazol 5 yl 1e 3 butadienyl 4 hydroxy 3 4 5 6 tetrahydro 2h pyran 2 one. Journal of Labelled Compounds & Radiopharmaceuticals 29(2): 193-200, 1991

Studies on the metabolism and disposition of the new retinoid 4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl)benzoic acid: 5th Communication: Factors affecting percutaneous absorption in rats. Arzneimittel Forschung 47(3): 270-275, 1997

Studies on the metabolism and disposition of the new retinoid 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]benzoic acid. 3rd communication: placental transfer and excretion into milk in rats. Arzneimittel-Forschung 47(2): 201-208, 1997

Studies on the metabolism and disposition of the new retinoid 4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl) benzoic acid: 3rd communication: Placental transfer and excretion into milk in rats. Arzneimittel Forschung 47(2): 201-208, 1997

Studies on the metabolism and disposition of the new retinoid 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]benzoic acid. 5th communication: factors affecting percutaneous absorption in rats. Arzneimittel-Forschung 47(3): 270-275, 1997