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T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus



T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus



Immunology 99(3): 345-351



The (New Zealand black (NZB) X New Zealand white (NZW))F1 (NZB/W) mouse strain spontaneously develops an autoimmune disease characterized by anti-dsDNA antibody production and glomerulonephritis. Although evidence suggests that production of pathogenic autoantibodies is T-cell dependent, the immunological defects that lead to activation of these autoreactive T cells are unknown.

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Accession: 011449065

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PMID: 10712663


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