+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitro



Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitro



Journal of Infectious Diseases 187(6): 946-955



CD8(+) T cell immunity is critical for protection from viral disease, such as that caused by the human immunodeficiency virus (HIV) or cytomegalovirus (CMV). It is therefore important to identify therapies that can boost antiviral immunity. The recent finding that thalidomide acts as a T cell costimulator suggested that this drug may boost antiviral CD8(+) T cell responses. In this in vitro study, in a human autologous CD8(+) T cell/dendritic cell (DC) coculture system, thalidomide and a potent thalidomide analogue were shown to enhance virus-specific CD8(+) T cell cytokine production and cytotoxic activity. The drug-enhanced antiviral activity was noted in cells from both healthy donors and persons chronically coinfected with HIV and CMV. This stimulatory effect was directed at CD8(+) T cells, and not DCs. These results suggest an application for thalidomide and the thalidomide analogue as a novel immune-adjuvant therapy in chronic viral infections.

(PDF emailed within 0-6 h: $19.90)

Accession: 011463053

Download citation: RISBibTeXText

PMID: 12660941

DOI: 10.1086/368126



Related references

Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. Journal of Neuro-Oncology 43(2): 109-114, 1999

Combined radiotherapy and thalidomide or the thalidomide analogue 3APG in an intracranial glioblastoma model. Proceedings of the American Association for Cancer Research Annual Meeting 43: 480, March, 2002

Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue. Organic & Biomolecular Chemistry 8(18): 4059-4062, 2010

Thalidomide metabolites and analogues. 3. Synthesis and antiangiogenic activity of the teratogenic and TNFalpha-modulatory thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine. Journal of Medicinal Chemistry 46(18): 3793-3799, 2003

Thalidomide can costimulate or suppress CD4+ cells' ability to incorporate [H3]-thymidine--dependence on the primary stimulant. International Immunopharmacology 2(8): 1143-1153, 2002

Thalidomide--failure or success? A controversial drug during the last fifty years--the pendulum swings--a renaissance for thalidomide?. Ugeskrift for Laeger 162(1): 52-53, 2000

Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro. Aids Research and Human Retroviruses 13(10): 857-863, 1997

Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. leprae-induced TNFalpha production in vitro. Biomedicine & PharmacoTherapy 56(1): 13-19, 2002

Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide. Plos One 10(4): E0123094-E0123094, 2016

The thalidomide analogue, CC-4047, induces apoptosis signaling and growth arrest in childhood acute lymphoblastic leukemia cells in vitro and in vivo. Clinical Cancer Research 12(18): 5526-5532, 2006

The effects of thalidomide on meristematic cells. I. The cytological test on monoethanolamin, for solvent of thalidomide. Senshokutai (Chromosome)/Kromosomo, 41: 2113-20, 1966

Thalidomide and thalidomide transformed by pH-dependent hydrolysis or by liver enzyme treatment does Not impede the proliferation of endothelial cells. Immunopharmacology and Immunotoxicology 30(2): 307-316, 2008

Hematological changes caused by treatment with thalidomide in Columba livia Gm. II. Thalidomide and number of cells in peripheral blood after bloodletting. Bollettino Della Societa Italiana di Biologia Sperimentale 43(17): 1043-1046, 1967

Teratogen metabolism activation of thalidomide and thalidomide analogs to products that inhibit the attachment of cells to concanavalin a coated plastic surfaces. Biochemical Pharmacology 33(9): 1471-1478, 1984

Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human fetal skin fibroblasts and in rat liver epithelial cells. Biochemical Pharmacology 62(8): 1081-1086, 15 October, 2001