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The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis



The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis



Biochimica et Biophysica Acta 1498(2-3): 153-161, 20 December



During the development of an organism cell proliferation, differentiation and cell death are tightly balanced, and are controlled by a number of different regulators. Alterations in this balance are often observed in a variety of human diseases. The role of Ca(2+) as one of the key regulators of the cell is discussed with respect to two recently discovered proteins, ALG-2 and AIP, of which the former is a Ca(2+)-binding protein, and the latter is substrate to various kinases. The two proteins interact with each other in a Ca(2+)-dependent manner, and the role of the complex ALG-2/AIP as a possible modulator at the interface between cell proliferation and cell death is discussed.

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Accession: 011464460

Download citation: RISBibTeXText

PMID: 11108958

DOI: 10.1016/s0167-4889(00)00091-4


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