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Chapter 11,473

The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling

Gupta, N.; Scharenberg, A.M.; Fruman, D.A.; Cantley, L.C.; Kinet, J.P.; Long, E.O.

Journal of Biological Chemistry 274(11): 7489-7494

1999


ISSN/ISBN: 0021-9258
PMID: 10066815
Accession: 011472351

Coligation of FcgammaRIIb1 with the B cell receptor (BCR) or FcepsilonRI on mast cells inhibits B cell or mast cell activation. Activity of the inositol phosphatase SHIP is required for this negative signal. In vitro, SHIP catalyzes the conversion of the phosphoinositide 3-kinase (PI3K) product phosphatidylinositol 3,4,5-trisphosphate (PIP3) into phosphatidylinositol 3,4-bisphosphate.

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