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The common mitochondrial DNA deletion DELTAmtDNA4977: Sheding new light to the concept of a tumor suppressor mutation



The common mitochondrial DNA deletion DELTAmtDNA4977: Sheding new light to the concept of a tumor suppressor mutation



Medical Hypotheses 61(1): 60-63



We propose that the age-related accumulation of DELTAmtDNA4977 mutations may serve a protective function against tumor-promoting effects of other somatic mutations. The evidence discussed here is consistent with the concept that DELTAmtDNA4977 plays a tumor-suppressor role, thus sheding new light to the concept of a tumor suppressor mutation. This concept may help understand how a tumor-promoting mutation may be able to cause malignant transformation in cells lacking a tumor-suppressor mutation, while the same tumor-promoting mutation can be present in cells that carry a tumor-suppressor mutation, without causing cancer.

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Accession: 011483980

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PMID: 12781642


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