+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effects of pressurization rate on breathing pattern, work of breathing, gas exchange and patient comfort in pressure support ventilation

The effects of pressurization rate on breathing pattern, work of breathing, gas exchange and patient comfort in pressure support ventilation

European Respiratory Journal 18(1): 107-114

The aim of this study was to investigate the effects of different pressurization rates during pressure support ventilation on breathing pattern, work of breathing, gas exchange and patient comfort in patients with acute lung injury. The pressurization rate modifies the initial pressure ramp by changing the initial peak flow rate: the increase in pressurization rate is associated with a decrease in the time to reach the level of pressure support ventilation by increasing the peak flow rate. Ten intubated patients (age 64+/-17 yrs, body mass index 24+/-17 Kg x m(-2), arterial oxygen tension/inspired oxygen fraction 214+/-59) were studied in random order varying the pressurization rate at 5 and 15 cmH2O of pressure support ventilation. Breathing comfort was evaluated by a visual analogue scale. Increasing the pressurization rate caused an increase of peak flow rate from 473+/-141 mL x s(-1) to 758+/-302 mL x s(-1) at pressure support ventilation 5 (p<0.05) and from 481+/-126 mL x s(-1) to 1,121+/-175 mL x s(-1) at pressure support ventilation 15 (p<0.05). At the lowest pressurization rate the tidal volume was the lowest, the respiratory rate and the work of breathing were the highest (p<0.05) compared with other pressurization rates. Excluding the lowest pressurization rate, in all the other pressurization rates tested the breathing pattern and the work of breathing did not change. The lowest and the highest pressurization rates caused the worst patient comfort (p<0.05). The gas exchange was stable throughout the study. The presented results suggest: 1) the lowest pressurization rate caused the lowest tidal volume, highest respiratory rate and highest work of breathing; 2) at the other pressurization rates no differences in breathing pattern and work of breathing were observed; and 3) the patient's comfort was worse at the lowest and highest pressurization rates.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 011501931

Download citation: RISBibTeXText

PMID: 11510780

Related references

Additional views in radiographic technique. Radiography 16(189): 190-192, 1950

Relationships between preoperative conditions and prognosis in aged patients with femoral neck fractures. Orthopedic Surgery 43(7): 925-928, 1992

Cycling-off criteria during pressure support ventilation: what do we have to monitor?. Journal of Critical Care 29(3): 457-458, 2014

Effect of different levels of lipid peroxidation on continous intravascular blood coagulation. Biomeditsinskaia Khimiia 51(4): 424-431, 2005

Polysomnography in Chronic Neuromuscular Disease. Respiration 70(4): 349-354, 2003

Breathing for protein function of (proton) homeostasis. Respiration Physiology 93(1): 1-12, 1993

Use of the rapid assessment method in maternity care: A practical example. Saudi Medical Journal 17(6): 744-751, 1996

Rate of postmortem tenderization in normal and callipyge lamb. Journal of Animal Science 74(Suppl. 1): 164, 1996

Breathing out into water during subtotal immersion: a therapy for chronic pulmonary emphysema. American Journal of Physical Medicine and Rehabilitation 79(2): 150-153, 2000

Effects of pressure overload on the passive mechanisms of the rat left ventricle. Annals of Biomedical Engineering 23(2): 152-163, 1995

Respiratory circuits and infections of the airway. Minerva Anestesiologica 63(10): 327-335, 1997

Breathing pattern and workload during automatic tube compensation, pressure support and T-piece trials in weaning patients. European Journal of Anaesthesiology 20(1): 10-16, 2003

Comparison of work of breathing between volume support and pressure support in young lambs with and without increased resistance. Journal of Investigative Medicine 43(Suppl. 1): 74A, 1995

The effect of pressure on fluid absorption during endometrial ablation. Journal of Gynecologic Surgery 8(1): 1-10, 1992

Work of breathing during mechanical ventilation as a function of peak inspiratory flow rate. 1985