+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The functional anatomy of the normal human auditory system: responses to 0.5 and 4.0 kHz tones at varied intensities

The functional anatomy of the normal human auditory system: responses to 0.5 and 4.0 kHz tones at varied intensities

Cerebral Cortex 9(1): 65-76

Most functional imaging studies of the auditory system have employed complex stimuli. We used positron emission tomography to map neural responses to 0.5 and 4.0 kHz sine-wave tones presented to the right ear at 30, 50, 70 and 90 dB HL and found activation in a complex neural network of elements traditionally associated with the auditory system as well as non-traditional sites such as the posterior cingulate cortex. Cingulate activity was maximal at low stimulus intensities, suggesting that it may function as a gain control center. In the right temporal lobe, the location of the maximal response varied with the intensity, but not with the frequency of the stimuli. In the left temporal lobe, there was evidence for tonotopic organization: a site lateral to the left primary auditory cortex was activated equally by both tones while a second site in primary auditory cortex was more responsive to the higher frequency. Infratentorial activations were contralateral to the stimulated ear and included the lateral cerebellum, the lateral pontine tegmentum, the midbrain and the medial geniculate. Contrary to predictions based on cochlear membrane mechanics, at each intensity, 4.0 kHz stimuli were more potent activators of the brain than the 0.5 kHz stimuli.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 011508905

Download citation: RISBibTeXText

PMID: 10022496

DOI: 10.1093/cercor/9.1.65

Related references

Evaluation of the functional significance of the electrical responses of the auditory system (responses to exponentially increasing broad-band noises and tones). Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 48: 1178-1186, 1962

Amplitude and latency studies of the averaged auditory evoked responses to tones of different intensities. Acta Oto-Laryngologica 76(6): 395-401, 1973

Evaluation of Functional Significance of Auditory System Responses to Exponentially Increasing Wide-Band Noises and Tones. Federation Proceedings. Translation Supplement; Selected Translations from Medical-Related Science 23: 275-279, 1964

Functional studies of the human auditory pathway after monaural stimulation with pure tones. Establishing a normal database. Acta Oto-Laryngologica 125(5): 513-519, 2005

Responses of the auditory system to complex tones. Audiology Japan 34(1): 58-66, 1991

Normal infant and adult auditory brainstem responses to bone-conducted tones. Audiology (basel). 32(2): 95-109, 1993

Functional organization of squirrel monkey primary auditory cortex: responses to pure tones. Journal of Neurophysiology 85(4): 1732-1749, 2001

The effects of monotic and dichotic interference tones on 40 Hz auditory steady-state responses in normal-hearing adults. Journal of the American Academy of Audiology 19(2): 101-119, 2008

Auditory cortical responses evoked by pure tones in healthy and sensorineural hearing loss subjects: functional MRI and magnetoencephalography. Chinese Medical Journal 119(18): 1548-1554, 2006

Representation of tonal consonance and dissonance in the temporal firing patterns of auditory nerve fibers Responses to musical intervals composed of pure tones vs harmonic complex tones. Society for Neuroscience Abstracts 18(1-2): 382, 1992

Human auditory sensitivity to low frequency tones in the normal state and in various forms of deafness. Zhurnal Ushnykh Nosovykh i Gorlovykh Boleznei 28(1): 4-9, 1968

Activation of human auditory cortex during passive listening to FM tones demonstrated with functional MRI. Society for Neuroscience Abstracts 22(1-3): 1070, 1996

Human auditory steady-state responses to tones independently modulated in both frequency and amplitude. Ear and Hearing 22(2): 100-111, 2001

Functional studies (NeuroSPECT) of the human auditory pathway after stimulating binaurally with pure tones. Acta Oto-Laryngologica 131(4): 371-376, 2011