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The hemodynamic inverse problem: making inferences about neural activity from measured MRI signals



The hemodynamic inverse problem: making inferences about neural activity from measured MRI signals



Proceedings of the National Academy of Sciences of the United States of America 100(5): 2177-2179



The structure of the voltage sensor and the detailed physical basis of voltage-dependent activation in ion channels have not been determined. We now have identified conserved molecular rearrangements underlying two major voltage-dependent conformational changes during activation of divergent K(+) channels, ether-à-go-go (eag) and Shaker. Two conserved arginines of the S4 voltage sensor move sequentially into an extracellular gating pocket, where they interact with an acidic residue in S2.

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Accession: 011511691

Download citation: RISBibTeXText

PMID: 12606715

DOI: 10.1073/pnas.0630492100


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