+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The molecular basis for the generation of Hodgkin and Reed-Sternberg cells in Hodgkin's lymphoma



The molecular basis for the generation of Hodgkin and Reed-Sternberg cells in Hodgkin's lymphoma



International Journal of Hematology 77(4): 330-335



Hodgkin's lymphoma (HL) is a lymphoid neoplasm with a low frequency of malignant tumor cells, known as Hodgkin and Reed-Sternberg (H-RS) cells, in a background of mixed cellular infiltrates. Despite extensive studies on H-RS cells, the molecular mechanisms of their growth and regulation have remained uncertain for a long period. Recently, constitutively activated nuclear factor-kappaB (NF-kappaB) was reported to be a unique and common characteristic of H-RS cells that prevents the cells from undergoing apoptosis. NF-kappaB triggers proliferation and provides a molecular basis for these cells' aberrant growth and cytokine gene expression. In HL pathogenesis associated with Epstein-Barr virus infection, the activation of NF-kappaB is induced by viral latent membrane protein 1 (LMP1). Coupled with recent insights into the molecular mechanisms of activation of NF-kappaB signaling in H-RS cells, this review discusses a linkage between LMP1 and HL via CD99, which has recently been reported to be down-regulated by LMP1 through the NF-kappaB signaling pathway. This down-regulation leads to the generation of cells with H-RS phenotypes related to the clinical and histologic characteristics of HL.

(PDF emailed within 0-6 h: $19.90)

Accession: 011526160

Download citation: RISBibTeXText

PMID: 12774919

DOI: 10.1007/bf02982639


Related references

Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cells. Lancet. Oncology 5(1): 11-18, 2004

Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma. International Journal of Cancer 118(8): 1853-1861, 2005

An immunohistochemical analysis of Reed-Sternberg-like cells in posttransplantation lymphoproliferative disorders: The possible pathogenetic relationship to Reed-Sternberg cells in Hodgkin's disease and Reed-Sternberg-like cells in non-Hodgkin's lymphomas and reactive conditions. Human Pathology 28(4): 493-498, 1997

Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma. Blood 120(23): 4609-4620, 2013

Epstein-Barr virus (EBV) positive classical Hodgkin lymphoma of Iraqi children: an immunophenotypic and molecular characterization of Hodgkin/Reed-Sternberg cells. Pediatric Blood & Cancer 60(12): 2068-2072, 2013

Molecular karyotypes of Hodgkin and Reed-Sternberg cells at disease onset reveal distinct copy number alterations in chemosensitive versus refractory Hodgkin lymphoma. Clinical Cancer Research 17(10): 3443-3454, 2011

Cytokine gene expression in Hodgkin and Reed-Sternberg cells of Hodgkins disease by single-cell global PCR IL-1 and TNF-alpha but not IL-2, IL-4 and IFN-gamma are produced by Hodgkin and Reed-Sternberg cells. Blood 86(10 SUPPL 1): 179A, 1995

Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells. Blood 100(12): 4139-4145, 2002

Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient. Blood 87(8): 3429-3436, 1996

Apoptosis of Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma revisited. Apmis 118(5): 339-345, 2010

Paediatric Hodgkin lymphoma with Reed-Sternberg and mononuclear Hodgkin cells in the bone marrow aspirate. British Journal of Haematology 157(1): 2-2, 2013