+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Theophylline in snoring and sleep-related breathing disorders: sleep laboratory investigations on subjective and objective sleep and awakening quality

Theophylline in snoring and sleep-related breathing disorders: sleep laboratory investigations on subjective and objective sleep and awakening quality

Methods and Findings in Experimental and Clinical Pharmacology 22(4): 237-245

The aim of the present investigation was to comparatively examine the effect of theophylline on various sleep-related breathing disorders of different severity. In a single-blind, placebo-controlled crossover study, 30 patients were polysomnographically diagnosed as suffering from primary snoring (n = 7), obstructive snoring (n = 12) or moderate sleep apnea (n = 11). Subsequent polysomnographic investigations included one baseline, one placebo and one theophylline (Respicur(R) retard 400 mg, Byk Gulden, Konstanz, Germany) night. Subjective sleep and awakening quality was evaluated by means of a test battery completed in the morning. Concerning respiratory variables, theophylline was most effective in patients with moderate sleep apnea. Obstructive snorers only showed a tendency towards improvement and primary snorers remained unchanged. Sleep architecture generally remained unchanged in all three patient groups. Objective awakening quality was partly improved in primary snorers, obstructive snorers, as well as in moderate sleep apnea patients as compared with baseline, but not as compared with placebo. Regarding subjective sleep and awakening quality, only primary snorers and obstructive snorers showed an improvement, as compared with baseline while moderate sleep apnea patients remained unchanged. Based on intergroup comparison, we conclude that patients with moderate sleep apnea showed the most pronounced improvement in regard to respiratory events. Concerning sleep initiation and maintenance, sleep architecture and subjective sleep and awakening quality, no significant intergroup differences were found. Regarding objective awakening quality, attention showed a significantly greater improvement in primary than in obstructive snorers and sleep apnea patients, while motor performance was most improved in obstructive snorers.

(PDF emailed within 1 workday: $29.90)

Accession: 011561099

Download citation: RISBibTeXText

PMID: 10939035

Related references

Efficiency of continuous positive airway pressure versus theophylline therapy in sleep apnea: comparative sleep laboratory studies on objective and subjective sleep and awakening quality. Neuropsychobiology 39(3): 151-159, 1999

Placebo-controlled sleep laboratory studies on the acute effects of zolpidem on objective and subjective sleep and awakening quality in nonorganic insomnia related to neurotic and stress-related disorder. Neuropsychobiology 41(3): 139-148, 2000

Quality of life in nonorganic and organic sleep disorders: II. Correlation with objective and subjective quality of sleep and awakening. Wiener Klinische Wochenschrift 115(10): 326-333, 30 Mai, 2003

Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole. 1. Findings on objective and subjective sleep and awakening quality. Neuropsychobiology 41(4): 181-189, 2000

The prevalence of snoring sleep disturbance and sleep related breathing disorders and their relation to daytime sleepiness in 4 5 year old children. American Review of Respiratory Disease 143(4 PART 2): A391, 1991

Upper airway patency and nocturnal desaturation in habitual snoring and obstructive sleep apnea: pathogenesis of sleep-related breathing disorders. European Neurology 36(4): 206-210, 1996

Long-term subjective and objective sleep analysis of total sleep time and sleep quality in real life settings. Conference Proceedings 2007: 5202-5205, 2007

Objective and subjective socioeconomic gradients exist for sleep quality, sleep latency, sleep duration, weekend oversleep, and daytime sleepiness in adults. Behavioral Sleep Medicine 11(2): 144-158, 2013

Guidelines for diagnosis and treatment of sleep-related breathing disorders in adults and children. Definition and classification of sleep related breathing disorders in adults: different types and indications for sleep studies (Part 1). Hippokratia 13(3): 187-191, 2009

How is the Epworth Sleepiness Scale related with subjective sleep quality and polysomnographic features in patients with sleep-disordered breathing?. Sleep & Breathing 15(3): 513-518, 2012

Snoring and sleep-disordered breathing in young children: subjective and objective correlates. Sleep 27(1): 87-94, 2004

The use of a mobile sleep laboratory in diagnosing sleep-related breathing disorders. Journal of Medical Engineering & Technology 13(1-2): 100-103, 1989

Age-related sleep change: Gender and estrogen effects on the subjective-objective sleep quality relationships of healthy, noncomplaining older men and women. Journal of Psychosomatic Research 56(5): 503-510, 2004

Therapy for sleep-related breathing disorders using positive airway pressure. Data from an HNO sleep laboratory. Hno 54(1): 25-33, 2005

Neurology of sleep and sleep-related breathing disorders and their relationships to sleep bruxism. Journal of the California Dental Association 40(2): 159-167, 2012