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Three-drug schemes of immunosuppression and morphological and immunohistochemical changes of the transplant in immediate postoperative period

Three-drug schemes of immunosuppression and morphological and immunohistochemical changes of the transplant in immediate postoperative period

Urologiya (Moscow) (5): 30-33, September-October

Three-component (cyclosporin A, corticosteroids and azathioprine) immunosuppression has been widely introduced in the treatment of recipients of renal transplants because it allows a significant reduction of the components' doses in greater effectiveness. The analysis of the results of 83 puncture biopsies obtained in the immediate postoperative period after kidney transplantation has shown that administration of an imidazole derivative allows raising therapeutic concentration of cyclosporin up to 200-300 ng/ml, thus preventing rejection crises. However, increased blood concentration of cyclosporin does not increase its toxicity as a result of a significant fall in the overall level of the metabolites.

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