Section 12
Chapter 11,583

Transcriptional activation of the promoter of human cytomegalovirus immediate early gene (CMV-IE) by the hepatitis B viral X protein (HBx) through the NF-kappaB site

Assogba, B.Dossou.; Choi, B.Hyune.; Rho, H.Mo.

Virus Research 84(1-2): 171-179


ISSN/ISBN: 0168-1702
PMID: 11900849
Accession: 011582322

The reactivation of latent cytomegalovirus (CMV) in a human by another viral infection may induce virus-related symptoms. Based on this presumption, we investigated the effect of HBx on the activation of the CMV-IE, which is also known as a transactivator and potential oncogene. The HBx transactivated the CMV-IE promoter by up to 4- and 18-fold factors in human liver HepG2 and lung fibroblast MRC-5 cells, respectively.

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