EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Tree-based recursive partitioning methods for subdividing sibpairs into relatively more homogeneous subgroups


Tree-based recursive partitioning methods for subdividing sibpairs into relatively more homogeneous subgroups



Genetic Epidemiology 20(3): 293-306



ISSN/ISBN: 0741-0395

PMID: 11255239

DOI: 10.1002/gepi.1

We propose a new splitting rule for recursively partitioning sibpair data into relatively more homogeneous subgroups. This strategy is designed to identify subgroups of sibpairs such that within-subgroup analyses result in increased power to detect linkage using Haseman-Elston regression. We assume that the subgroups can be defined by patterns of non-genetic binary covariates measured on each sibpair. The data we consider consists of the squared difference of a quantitative trait measurement on each sibpair, estimates of identity-by-descent (IBD) values at each genetic marker, and binary covariate data describing characteristics of the sibpair (e.g., race, sex, family history of disease). To test the efficacy of this method in linkage analysis, we performed two simulation experiments. In the first, we simulated a mixture consisting of 66.6% of the sibpairs with no linkage and 33.3% of the sibpairs with genetic linkage to one marker. The two groups were distinguished by the value of a single binary covariate. We also simulated one unlinked marker and one random covariate to include as noise in the data. In the second experiment, we simulated a mixture consisting of 55% of the sibpairs with no genetic linkage, 22.5% of the sibpairs with genetic linkage to one marker, and 22.5% of the sibpairs with linkage to a different marker. Each subgroup was defined by a distinct pattern of two binary covariates. We also simulated one unlinked marker and two random covariates to include as noise in the data. Our simulation studies found that we can significantly increase the overall power to detect linkage by fitting Haseman-Elston regression models to homogeneous subgroups with only a small increase in the false-positive rate. Second, the splitting rule can correctly identify important covariates and linked markers. Third, recursive partitioning of sibpair data using this splitting rule can correctly identify sibpair subgroups. These results indicate that partitioning sibpairs into homogeneous subgroups is feasible and significantly increases the power to detect linkage, thus demonstrating the practical utility and potential this new methodology holds.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011594020

Download citation: RISBibTeXText

Related references

Identifying Homogeneous Subgroups in Neurological Disorders: Unbiased Recursive Partitioning in Cervical Complete Spinal Cord Injury. Neurorehabilitation and Neural Repair 28(6): 507-515, 2014

Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies. Annals of Human Genetics 69(Pt 5): 577-589, 2005

Detection of Problem Gambler Subgroups Using Recursive Partitioning. International Journal of Mental Health and Addiction 11(3): 281-291, 2013

Classification algorithms for hip fracture prediction based on recursive partitioning methods. Medical Decision Making: An International Journal of the Society for Medical Decision Making 24(4): 386-398, 2004

Hip fracture prediction from a new classification algorithm based on recursive partitioning methods. Journal of Applied Statistics 40(6): 1246-1253, 2013

Radiation dose requirements for favorable risk prostate cancer subgroups using recursive partitioning. International Journal of Radiation Oncology Biology Physics 54(2 Suppl): 277-278, 2002

Recursive partitioning for the identification of disease risk subgroups: A case-control study of subarachnoid hemorrhage. Journal of Clinical Epidemiology 51(3): 199-209, 1998

Possibility for subdividing apparently homogeneous depositional sequences by combined use of sedimentological, palaeontological and mathematical methods. GeoJournal 36(2-3): 169-177, 1995

Possibility for subdividing apparently homogeneous rock sequences by combined use of sedimentological paleontological and mathematical methods. Foldtani Kozlony 111(2): 238-257, 1981

Using recursive partitioning to account for parameter heterogeneity in multinomial processing tree models. Behavior Research Methods 50(3): 1217-1233, 2018

A preliminary empirical comparison of recursive neural networks and tree kernel methods on regression tasks for tree structured domains. Neurocomputing 64: 73-92, 2005

Data mining for response shift patterns in multiple sclerosis patients using recursive partitioning tree analysis. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment Care and Rehabilitation 20(10): 1543-1553, 2011

Adaptive semi-supervised recursive tree partitioning: The ART towards large scale patient indexing in personalized healthcare. Journal of Biomedical Informatics 55: 41-54, 2015

Binary recursive partitioning: background, methods, and application to psychology. British Journal of Mathematical and Statistical Psychology 64(Pt 1): 161-181, 2011

Using recursive partitioning analysis to evaluate compound selection methods. Methods in Molecular Biology 275: 317-334, 2004