+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ultrastructural clues for glutamate-induced necrosis in parietal and cerebellar neurons

Ultrastructural clues for glutamate-induced necrosis in parietal and cerebellar neurons

Fundamental and Clinical Pharmacology 17(3): 341-347

Glutamate excitotoxicity has been postulated to underlie the neuronal death that occurs after ischemia. The most sensitive tissues to ischemic injury are hippocampus and cerebellum, whereas cerebrum is more resistant. We studied the glutamate-induced ultrastructural alterations in rat parietal and cerebellar neurons comparatively. We observed that glutamate (45 min, 10-7 M) causes considerable nuclear, mitochondrial and cytoplasmic changes in both the neuron types. Mitochondrial and nuclear changes were particularly more severe in cerebellar granular, than the ones in parietal neurons. It has been concluded that glutamate induces necrotic changes in both parietal and cerebellar neurons. But cerebellar cortex was found to be more sensitive to glutamate excitotoxicity than cerebral cortex. We suggest that mitochondrial damage is, probably, an important factor in neuron necrosis, which is mediated by glutamate excitotoxicity.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 011609304

Download citation: RISBibTeXText

PMID: 12803573

DOI: 10.1046/j.1472-8206.2003.00149.x

Related references

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. Journal of Neuroscience 27(31): 8238-8249, 2007

Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons. Neuropharmacology 37(7): 847-857, 1998

Synaptic effects induced in efferent neurons of the parietal associative cortex of the cat by stimulation of the cerebellar nuclei. Neurophysiology 27(3): 148-155, 1995

Ammonia prevents glutamate-induced but not low K+-induced apoptosis in cerebellar neurons in culture. Neuroscience 117(4): 899-907, 10 April, 2003

Glutamate induced gene expression in primary cerebellar neurons. Guidotti, A (Ed ) Fidia Research Foundation Symposium Series, Vol 4 Neurotoxicity Of Excitatory Amino Acids; Symposium, Scottsdale, Arizona, Usa, October 26-28, 1989 Xix+340p Raven Press: New York, New York, Usa Illus 185-202, 1990

Glutamate induced increase of calcium in neuronal cerebellar granule cultures studied at the ultrastructural level. Society for Neuroscience Abstracts 14(1): 421, 1988

Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity. Brain Research Bulletin 121: 241-245, 2016

Lithium activates Akt and suppresses glutamate-induced inhibition of Akt in cerebellar granule neurons. Society for Neuroscience Abstracts 25(1-2): 600, 1999

Interleukin-6 prevents cultured cerebellar granule neurons from glutamate-induced neurotoxicity. Zhongguo Ying Yong Sheng Li Xue Za Zhi 22(3): 310-315, 2006

Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Neuroscience Letters 374(3): 192-196, 2005

The effects of intracellular chloride ions on glutamate-induced IP-3 production in cerebellar neurons. Japanese Journal of Pharmacology 61(Suppl. 1): 326P, 1993

Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons. Journal of Neurochemistry 92(5): 1081-1090, 2005

Alcohol-induced changes in the developing cerebellum. Ultrastructural and quantitative analysis of neurons in the cerebellar cortex. Folia Neuropathologica 50(4): 397-406, 2012

Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain Research 924(2): 229-236, 2002

Heterogeneity of intracellular calcium responses induced by metabotropic glutamate receptor agonists in cerebellar neurons. Society for Neuroscience Abstracts 19(1-3): 295, 1993