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Vaccine of recombinant plasmid pcDNA3-pacA and pcDNA3-pacP against dental caries in gnotobiotic rats I: Experimental caries score



Vaccine of recombinant plasmid pcDNA3-pacA and pcDNA3-pacP against dental caries in gnotobiotic rats I: Experimental caries score



Journal of West China University of Medical Sciences 33(3): 347-349



Objective: To evaluate the effect of the vaccine of pcDNA3-pacA and pcDNA3-pacP against dental caries. Methods: Gnotobiotic rats were vaccinated with pcDNA3-pacA or/and pcDNA3-pacP through submaxillary gland. The keyes caries scores were calculated and compared. Results: The caries scores of the vaccinated rats were significantly higher than those of controls (P<0.05). The pcDNA3-pacP produced weaker effect than the pcDNA3-pacA (P<0.05). Conclusion: The recombinant plasmid pcDNA3-pacA and pcDNA3-pacP can be used as a novel gene vaccine against dental caries.

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