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Varicella vaccination in children with nephrotic syndrome: A report of the southwest pediatric nephrology study group



Varicella vaccination in children with nephrotic syndrome: A report of the southwest pediatric nephrology study group



Journal of Pediatrics 142(2): 145-148, February



Objective: To evaluate the safety and immunogenicity of varicella vaccine in children with nephrotic syndrome, including those taking low-dose, alternate-day prednisone. Study design: Prospective, open-label, multicenter clinical trial of varicella vaccine in a 2-dose regimen in US and Canadian children (12 months to <18 years) with nephrotic syndrome. Varicella Zoster Virus (VZV) antibody levels were measured after the first and second vaccine dose and yearly for 2 years. Patients were monitored for adverse reactions to vaccine, exposure to varicella, dermatomal zoster, and chickenpox. Results: Twenty-nine children, mean age 4.9 (SD 1.9) years, 45% receiving every-other-day steroids, received 2 vaccine doses. All patients seroconverted and had VZV antibody levels considered protective against breakthrough varicella (gtoreq5 gpELISA units) after 2 doses. At 2-year follow-up, all patients retained detectable antibody, and 91% (21 of 23) had levels gtoreq5 gpELISA units. There were no adverse events associated with vaccination. Conclusions: Varicella vaccine was generally well tolerated and highly immunogenic in children with nephrotic syndrome, including those on low-dose, alternate-day prednisone.

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Accession: 011635078

Download citation: RISBibTeXText

PMID: 12584535

DOI: 10.1067/mpd.2003.37



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