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Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals



Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals



Journal of Virology 76(23): 12344-12348, December



We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

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Accession: 011641504

Download citation: RISBibTeXText

PMID: 12414975

DOI: 10.1128/JVI.76.23.12344-12348.2002



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