EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci


WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci



Embo Journal 21(9): 2231-2241



ISSN/ISBN: 0261-4189

PMID: 11980720

DOI: 10.1093/emboj/21.9.2231

The Williams Syndrome Transcription Factor (WSTF), the product of the WBSCR9 gene, is invariably deleted in the haploinsufficiency Williams-Beuren Syndrome. Along with the nucleosome-dependent ATPase ISWI, WSTF forms a novel chromatin remodeling complex, WICH (WSTF-ISWI chromatin remodeling complex), which is conserved in vertebrates. The WICH complex was purified to homogeneity from Xenopus egg extract and was found to contain only WSTF and ISWI. In mouse cells, WSTF interacts with the SNF2H isoform of ISWI. WSTF accumulates in pericentric heterochromatin coincident with the replication of these structures, suggesting a role for WSTF in the replication of heterochromatin. Such a role is supported by the in vitro activity of both the mouse and frog WICH complexes: they are involved in the assembly of regular spaced nucleosomal arrays. In contrast to the related ISWI-interacting protein ACF1/WCRF180, WSTF binds stably to mitotic chromosomes. As dysfunction of other chromatin remodeling factors often has severe effects on development, haploinsufficiency of WSTF may explain some of the phenotypes associated with this disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011647194

Download citation: RISBibTeXText

Related references

Chromatin remodeling by WSTF-ISWI at the replication site: opening a window of opportunity for epigenetic inheritance?. Cell Cycle 4(4): 543-546, 2005

The WSTF-ISWI chromatin remodeling complex transiently associates with the human inactive X chromosome during late S-phase prior to BRCA1 and γ-H2AX. Plos one 7(11): E50023, 2012

An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nature Genetics 32(4): 627-632, 2002

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair. Journal of Cell Biology 207(6): 717-733, 2014

The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. Journal of Biological Chemistry 281(24): 16264-16271, 2006

The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. Nature Cell Biology 6(12): 1236-1244, 2004

Biological functions of the ISWI chromatin remodeling complex NURF. Genes and Development 16(24): 3186-3198, 2002

Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nature Structural and Molecular Biology 26(4): 258-266, 2019

Identification of the ISWI chromatin remodeling complex of the early branching eukaryote Trypanosoma brucei. Journal of Biological Chemistry 290(50): 29760, 2015

Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei. Journal of Biological Chemistry 290(45): 26954-26967, 2015

The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo. Molecular Cell 5(2): 355-365, 2000

SnapShot: Chromatin remodeling: ISWI. Cell 144(3): 453-453.E1, 2011

ISWI chromatin remodeling complexes in the DNA damage response. Cell Cycle 13(19): 3016-3025, 2014

ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell 90(1): 145-155, 1997

Kinetic proofreading in chromatin remodeling: the case of ISWI/ACF. Biophysical Journal 101(4): L30-L32, 2011