+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A developmental comparison of trace and delay eyeblink conditioning in rats using matching interstimulus intervals



A developmental comparison of trace and delay eyeblink conditioning in rats using matching interstimulus intervals



Developmental Psychobiology 47(1): 77-88



The effects of conditioning paradigm and interstimulus interval (ISI) were evaluated in this study of the development of associative learning in rats. The acquisition of classical eyeblink conditioning (EBC) was examined in two paradigms (trace vs. delay), with three different ISIs (short, medium, or long) at two ages (postnatal Days 21-23 or 29-31). These data provide the first parametric analysis of ISI in developing animals trained with trace EBC procedures. Further, by comparing trace and delay EBC, it was determined that when ISI is held constant, acquisition is similar for both conditioning paradigms regardless of developmental age. This suggests a similar ontogeny of associative processes for delay and trace EBC that relies on common neural substrates. However, conditioned response timing (onset and peak latencies) was affected by age and paradigm, suggesting that different neural mechanisms may play a role in timing delay versus trace conditioned responses.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011683132

Download citation: RISBibTeXText

PMID: 15959900

DOI: 10.1002/dev.20068


Related references

A comparison of delay and trace pavlovian eyeblink conditioning in developing rats. Society for Neuroscience Abstracts 22(1-3): 1648, 1996

Ontogeny of eyeblink conditioning in the rat: Effects of US intensity and interstimulus interval on delay conditioning. Psychobiology 21(3): 233-242, 1993

Effects of early hippocampal lesions on trace, delay, and long-delay eyeblink conditioning in developing rats. Neurobiology of Learning and Memory 76(3): 426-446, 2001

Trace eyeblink conditioning in patients with cerebellar degeneration: comparison of short and long trace intervals. Experimental Brain Research 187(1): 85-96, 2008

Comparison of trace and delay classical eyelid conditioning as a function of interstimulus interval. Journal of Experimental Psychology 91(1): 165-167, 1971

Variability in eyeblink classical conditioning and timed-interval tapping over five interstimulus intervals. Society for Neuroscience Abstracts 24(1-2): 164, 1998

Neonatal ethanol-induced deficits in acquisition and performance of eyeblink conditioning using different interstimulus intervals. Alcoholism Clinical & Experimental Research 26(5 Suppl.): 151A, 2002

Pavlovian conditioning of discriminatively elicited eyeblink responses with short onset latency attributable to lengthened interstimulus intervals. Brain Research 400(1): 171-175, 1987

Early hippocampal lesions differentially affect the development of delay and trace eyeblink conditioning in rats. Society for Neuroscience Abstracts 26(1-2): Abstract No -267 2, 2000

Classical eyeblink conditioning in adulthood: effects of age and interstimulus interval on acquisition in the trace paradigm. Psychology and Aging 6(1): 109-117, 1991

Developmental hypothyroidism impairs trace eyeblink conditioning in juvenile rats. Society for Neuroscience Abstracts 26(1-2): Abstract No -267 10, 2000

Choline supplementation mitigates trace, but not delay, eyeblink conditioning deficits in rats exposed to alcohol during development. Hippocampus 22(3): 619-630, 2012

Effects of neonatal alcohol dose and exposure window on long delay and trace eyeblink conditioning in juvenile rats. Behavioural Brain Research 236(1): 307-318, 2013

Differences between infants and adults in delay, long-delay, and trace eyeblink conditioning. Developmental Psychobiology 41(1): 79, 2002

The ontogeny of human learning in delay, long-delay, and trace eyeblink conditioning. Behavioral Neuroscience 117(6): 1196-1210, 2003