+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A dose ranging study of dexamethasone for preventing patient-controlled analgesia-related nausea and vomiting: A comparison of droperidol with saline



A dose ranging study of dexamethasone for preventing patient-controlled analgesia-related nausea and vomiting: A comparison of droperidol with saline



Anesthesia and Analgesia 98(4): 1066-1071



We designed this study to determine the minimum dose of dexamethasone for preventing nausea and vomiting associated with the use of morphine by patient-controlled analgesia (PCA). Two hundred forty female patients were randomly assigned to receive dexamethasone 2, 4, 8, or 12 mg IV immediately before induction of anesthesia. Droperidol (0.1 mg/mL with morphine 1 mg/mL in PCA pump) and saline were used as controls. The complete response (no postoperative nausea and vomiting and no need for rescue antiemetic for a 24-h postoperative period) rates for dexamethasone 8 mg (72.2%) and 12 mg (78.9%) were significantly more than for saline (42.9%) (P < 0.05). Patients who received dexamethasone 12 or 8 mg also reported higher patient satisfaction than those who received saline (P < 0.05). These results were as effective as adding droperidol 0.1 mg/mL to the morphine PCA without causing drowsiness, restlessness, or arrhythmias. Smaller doses of dexamethasone (4 or 2 mg) were not effective for this propose. The results suggest that dexamethasone 8 mg IV is the minimum effective dose for the reduction of PCA morphine-related nausea and vomiting. Morphine administration by patient-controlled analgesia (PCA) is often associated nausea and vomiting. In this double-blind study, the minimum effective dose of dexamethasone for reducing this complication was 8 mg. This was as effective as adding droperidol 0.1 mg/mL to the morphine PCA without causing drowsiness, restlessness or arrhythmias.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011683651

Download citation: RISBibTeXText

PMID: 15041600

DOI: 10.1213/01.ane.0000105875.05357.a0


Related references

Dexamethasone for prophylaxis of nausea and vomiting after epidural morphine for post-Caesarean section analgesia: comparison of droperidol and saline. British Journal of Anaesthesia 85(6): 865-868, 2000

Dexamethasone for prophylaxis of nausea and vomiting after epidural morphine for post-Caesarean section analgesia: comparison of droperidol and saline. British Journal of Anaesthesia 85(6): 865-868, 2000

Comparison of ondansetron and droperidol in reducing postoperative nausea and vomiting associated with patient-controlled analgesia. Anaesthesia 50(12): 1086-1088, 1995

A comparison of droperidol and cyclizine in the prevention of postoperative nausea and vomiting associated with patient-controlled analgesia. Anaesthesia 50(7): 654-656, 1995

Comparison of different methods of administering droperidol in patient-controlled analgesia in the prevention of postoperative nausea and vomiting. Anesthesia and Analgesia 80(1): 81-85, 1995

Comparison of droperidol vs tropisetron to prevent postoperative nausea and vomiting during patient-controlled analgesia with tramadol. European Journal of Anaesthesiology 18(Suppl. 21): 130-131, 2001

Comparison of dexamethasone with ondansetron or haloperidol for prevention of patient-controlled analgesia-related postoperative nausea and vomiting: a randomized clinical trial. World Journal of Surgery 36(4): 775-781, 2012

Randomised double-blind comparison of ondansetron and droperidol to prevent postoperative nausea and vomiting associated with patient-controlled analgesia. Anaesthesia 56(1): 60-65, 2001

The effect of dexamethasone upon patient-controlled analgesia-related nausea and vomiting. Anaesthesia 57(7): 705-709, 2002

Dexamethasone enhances the effect of tropisetron and ondansetron against nausea and vomiting against nausea and vomiting after patient-controlled analgesia. Di 1 Jun Yi Da Xue Xue Bao 22(2): 159-161, 2002

Dexamethasone for preventing nausea and vomiting associated with epidural morphine: a dose-ranging study. Anesthesia and Analgesia 92(3): 745-748, 2001

Dexamethasone for Preventing Nausea and Vomiting Associated with Epidural Morphine: A Dose-Ranging Study. Survey of Anesthesiology 46(1): 34-35, 2002

Comparison of palonosetron and dexamethasone with ondansetron and dexamethasone for postoperative nausea and vomiting in postchemotherapy ovarian cancer surgeries requiring opioid-based patient-controlled analgesia: A randomised, double-blind, active controlled study. Indian Journal of Anaesthesia 62(10): 773-779, 2018

Influence of droperidol on nausea and vomiting during patient-controlled analgesia. British Journal of Anaesthesia 73(4): 566-567, 1994

Influence of droperidol on nausea and vomiting during patient-controlled analgesia. British Journal of Anaesthesia 72(4): 460-461, 1994