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A pilot study of preirradiation chemotherapy and 1800 cGy craniospinal irradiation in young children with medulloblastoma



A pilot study of preirradiation chemotherapy and 1800 cGy craniospinal irradiation in young children with medulloblastoma



International Journal of Radiation Oncology, Biology, Physics 60(2): 531-536



Purpose: Craniospinal irradiation (CSI) is necessary in the treatment of medulloblastoma, although it results in significant long-term sequelae, particularly in young children. We prospectively evaluated the feasibility of giving preirradiation chemotherapy followed by 1800 cGy CSI to young children with localized medulloblastoma. Methods and Materials: Between January 1993 and July 1997, 7 consecutive patients (age, 20-64 months) with MO medulloblastoma were enrolled.

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Accession: 011701452

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PMID: 15380589

DOI: 10.1016/j.ijrobp.2004.03.027


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