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A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling

Jankov, R.P.; Kantores, C.; Belcastro, R.; Yi, S.; Ridsdale, R.A.; Post, M.; Tanswell, A.Keith.

American Journal of Physiology. Lung Cellular and Molecular Physiology 288(6): L1162-L1170

2005


ISSN/ISBN: 1040-0605
PMID: 15722379
DOI: 10.1152/ajplung.00180.2004
Accession: 011707734

Newborn rats exposed to 60% O-2 for 14 days develop endothelin (ET)-1-dependent pulmonary hypertension with vascular remodeling, characterized by increased smooth muscle cell (SMC) proliferation and medial thickening of pulmonary resistance arteries.

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