A single dose of intrathecal morphine in rats induces long-lasting hyperalgesia: the protective effect of prior administration of ketamine
Van Elstraete, A.C.; Sitbon, P.; Trabold, F.; Mazoit, J-Xavier.; Benhamou, D.
Anesthesia and Analgesia 101(6): 1750-1756
2005
ISSN/ISBN: 0003-2999 PMID: 16301254 DOI: 10.1213/01.ane.0000184136.08194.9b
Accession: 011709740
An active pronociceptive process involving N-methyl-D-aspartate (NMDA) receptor activation is initiated by opioid administration, leading to opioid-induced pain sensitivity. Experimental observations in rats have reported reduction of baseline nociceptive threshold after prolonged spinal opioid administration.
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