EurekaMag.com logo
+ Translate

Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine


, : Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine. Psychopharmacology 179(1): 136-143

Rationale: Sensitization to the effects of N-methyl-D-aspartate (NMDA) glutamate receptor antagonists is robust in animals. However, the applicability of this model to humans is unclear because it currently rests on highly confounded retrospective studies of individuals who experienced protracted psychoses following repeated binges with NMDA receptor antagonists. Objectives: The purpose of the current study was to determine whether there was evidence of sensitization to the behavioral effects of ketamine in healthy human subjects with repeated exposure to this drug. Methods: Data were studied from 295 healthy human subjects who participated in one or more of 11 separate studies that involved ketamine administration over 14 ye ars. Positive and negative symptoms (Brief Psychiatric Rating Scale: BPRS), perceptual alterations (Clinician-Administered Dissociative States Scale: CADSS), and "high" and "anxiety" states (Visual Analog Scale: VAS) that were measured in all studies were included as outcome measures. Results: After including the number of previous exposures, number of previous studies, and time since first exposure as variables, repeated exposure to ketamine did not result in increased behavioral responses, suggestive of behavioral sensitization. Conclusion: The current data do not provide evidence that repeated exposure to ketamine, albeit limited, is associated with sensitization to the behavioral effects of ketamine.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 011719004

PMID: 15682309

DOI: 10.1007/s00213-004-2066-5

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Harris A.R.; Lovegrove W.J., 1984: Visible persistence as a function of viewing condition and eye handedness relationship. Duration of visible persistence was investigated as a function of spatial frequency, orientation and viewing condition (binocular, dominant eye and non-dominant eye). Persistence increased with increasing spatial frequency and was longer for obliq...

Schwartz K.; Schubert G., 1973: Topology of induced lunar magnetic fields. Using the asymmetric theory of lunar induction derived by Schubertet al. (1973a), we have obtained the total and induced magnetic field line structure within the Moon and the diamagnetic cavity. Total field distributions are shown for orientations...

C. Ares; S. Khan; G. Gruber; A. MacArtain; G. Lutters; J. Heuberger; S. Bodis; A.J. Lomax, 2007: Postoperative proton radiotherapy for localized and loco-regional breast cancer: Potential for clinically relevant improvements?. International Journal of Radiation Oncology*Biology*Physics 69(3-supp-S): 0-0

Princen J.M.G.; Nieuwenhuizen W.; Mol Backx G.P.B.M.; Yap S.H., 1981: Direct evidence of transcriptional control of fibrinogen and albumin synthesis in rat liver during the acute phase response. Using immunoprecipitation technique, fibrinogen polypeptide mRNA were purified to homogeneity as demonstrated by translation in a wheat germ cell free system and by hybridization kinetics. By measuring the sequence contents of fibrinogen polypepti...

Stewart, H.; Jarrett, O.; Hosie, M.J.; Willett, B.J., 2011: Are endogenous feline leukemia viruses really endogenous?. Full length endogenous feline leukemia virus (FeLV) proviruses exist within the genomes of many breeds of domestic cat raising the possibility that they may also exist in a transmissible exogenous form. Such viruses would share receptor usage with...

Ellers, O., 1993: A mechanical, developmental morphospace classifies shapes of camarodont echinoids. American Zoologist 33(5): 71A

Gardemann, Andreas; Ohly, Dorothea; Fink, Monika; Katz, Norbert; Tillmanns, Harald; Hehrlein, Friedrich Wilhelm; Haberbosch, Werner, 1998: Association of the insertion/deletion gene polymorphism of the apolipoprotein B signal peptide with myocardial infarction. The Del allele of the apolipoprotein B (apoB) signal peptide (SP) insertion/deletion (Ins/Del) polymorphism has been shown to be associated with elevated plasma levels of apoB, cholesterol and low density lipoprotein. It was the aim of the present...

Thilmann, Christoph; Grosser, Karl-Heinz; Rhein, Bernhard; Zabel, Angelika; Wannenmacher, Michael; Debus, Juergen, 2002: Virtueller Bolus zur inversen Bestrahlungsplanung bei intensitaetsmodulierter Radiotherapie des Mammakarzinoms im Rahmen der adjuvanten Therapie. Background: Intensity modulated radiotherapy (IMRT) provides better sparing of normal tissue. We investigated the feasibility of inverse treatment planning for IMRT in adjuvant radiotherapy for breast cancer. Material and Methods: In addition to r...

Nakajo, Takeshi.; Funakawa, Satoshi., 1996: Eocene radiolarians from the lower formation of the Taishu Group, Tsushima Islands, Nagasaki Prefecture, Japan. Journal of the Geological Society of Japan. August; 1028: 751-754

Teixeira Noevaldo A.; Gonzaga Guilherme M.; Gaspar Jose C., 1996: Diamond geology; the Brazilian Cretaceous as an example. Boletim do Simposio sobre o Cretaceo do Brasil 4: 247-256