+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine

Psychopharmacology 179(1): 136-143
Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine
Rationale: Sensitization to the effects of N-methyl-D-aspartate (NMDA) glutamate receptor antagonists is robust in animals. However, the applicability of this model to humans is unclear because it currently rests on highly confounded retrospective studies of individuals who experienced protracted psychoses following repeated binges with NMDA receptor antagonists. Objectives: The purpose of the current study was to determine whether there was evidence of sensitization to the behavioral effects of ketamine in healthy human subjects with repeated exposure to this drug. Methods: Data were studied from 295 healthy human subjects who participated in one or more of 11 separate studies that involved ketamine administration over 14 ye ars. Positive and negative symptoms (Brief Psychiatric Rating Scale: BPRS), perceptual alterations (Clinician-Administered Dissociative States Scale: CADSS), and "high" and "anxiety" states (Visual Analog Scale: VAS) that were measured in all studies were included as outcome measures. Results: After including the number of previous exposures, number of previous studies, and time since first exposure as variables, repeated exposure to ketamine did not result in increased behavioral responses, suggestive of behavioral sensitization. Conclusion: The current data do not provide evidence that repeated exposure to ketamine, albeit limited, is associated with sensitization to the behavioral effects of ketamine.

(PDF same-day service: $19.90)

Accession: 011719004

PMID: 15682309

DOI: 10.1007/s00213-004-2066-5

Related references

Repeated exposure of adolescent rats to oral methylphenidate does not induce behavioral sensitization or cross-sensitization to nicotine. Brazilian Journal of Medical and Biological Research 43(7): 651-656, 2011

Repeated i.v. cocaine exposure produces long-lasting behavioral sensitization in pregnant adults, but behavioral tolerance in their offspring. Neuroscience 122(3): 579-583, 2003

Behavioral sensitization after repeated formaldehyde exposure in rats. Toxicology and Industrial Health 15(3-4): 346-355, 1999

Lack of behavioral sensitization after repeated exposure to THC in mice and comparison to methamphetamine. Psychopharmacology 193(4): 511-519, 2007

Behavioral and cross sensitization after repeated exposure to modafinil and apomorphine in rats. Chinese Journal of Physiology 53(5): 318-327, 2011

Effects of a subanaesthetic dose of ketamine on emotional and behavioral state in healthy subjects. Neurophysiologie Clinique 33(3): 138-147, 2003

Repeated ethanol intoxication induces behavioral sensitization in the absence of a sensitized accumbens dopamine response in C57BL/6J and DBA/2J mice. Neuropsychopharmacology 31(2): 396-405, 2005

Repeated exposure to lindane leads to behavioral sensitization and facilitates electrical kindling. Neurotoxicology & Teratology 17(2): 131-141, 1995

Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in rats. Psychopharmacology 154(2): 198-204, 2001

Behavioral sensitization and cross-sensitization following repeated treatments with cocaine and/or morphine. Society for Neuroscience Abstracts 22(1-3): 932, 1996