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Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation



Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation



Blood 106(9): 3285-3292



Inducible costimulator (ICOS) is expressed on activated and memory T cells and is involved in the regulation of cytokine production. We studied the role of ICOS on alloreactive T cells in graft versus host disease (GVHD) and determined that ICOS expression was up-regulated on alloreactive T cells in recipients of an allogeneic hematopoietic stem cell transplantation (allo-HSCT) with GVHD. We compared ICOS-/- T cells with wild-type (WT) T cells in 2 GVHD models.

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Accession: 011719122

Download citation: RISBibTeXText

PMID: 15956289

DOI: 10.1182/blood-2005-01-0410


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