Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death
Manabe, S-Ichi.; Gu, Z.; Lipton, S.A.
IOVS Investigative Ophthalmology and Visual Science 46(12): 4747-4753
2005
ISSN/ISBN: 0146-0404 PMID: 16303975 DOI: 10.1167/iovs.05-0128
Accession: 011724667
PURPOSE. Understanding the mechanism of neuronal cell death in retinal diseases like glaucoma is important for devising new treatments. One factor involves excitatory amino acid stimulation of N-methyl-D-aspartate (NMDA)-type glutamate receptors, excessive Ca2+ influx, and formation of nitric oxide ( NO) via neuronal NO synthase ( nNOS).
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