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Allelic variation of HERV-K(HML-2) endogenous retroviral elements in human populations



Allelic variation of HERV-K(HML-2) endogenous retroviral elements in human populations



Journal of Molecular Evolution 59(5): 642-656



Human endogenous retroviruses (HERVs) are the remnants of ancient germ cell infection by exogenous retroviruses and occupy up to 8% of the human genome. It has been suggested that HERV sequences have contributed to primate evolution by regulating the expression of cellular genes and mediating chromosome rearrangements. After integration apprx28 million years ago, members of the HERV-K (HML-2) family have continued to amplify and recombine.

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Accession: 011740264

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PMID: 15693620

DOI: 10.1007/s00239-004-2656-1


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