+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Allelic variation of HERV-K(HML-2) endogenous retroviral elements in human populations

Allelic variation of HERV-K(HML-2) endogenous retroviral elements in human populations

Journal of Molecular Evolution 59(5): 642-656

Human endogenous retroviruses (HERVs) are the remnants of ancient germ cell infection by exogenous retroviruses and occupy up to 8% of the human genome. It has been suggested that HERV sequences have contributed to primate evolution by regulating the expression of cellular genes and mediating chromosome rearrangements. After integration apprx28 million years ago, members of the HERV-K (HML-2) family have continued to amplify and recombine.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 011740264

Download citation: RISBibTeXText

PMID: 15693620

DOI: 10.1007/s00239-004-2656-1

Related references

Coamplification and dispersion of adjacent human endogenous retroviral HERV-H and HERV-E elements; presence of spliced hybrid transcripts in normal leukocytes. Virology 244(1): 219-229, 1998

Nonrandom distribution of the endogenous retroviral regulatory elements HERV-K LTR on human chromosome 22. Doklady Biochemistry 372(1-6): 87-89, 2000

Nonrandom distribution of endogenous retroviral regulatory elements, HERV-K LTRs, on human Chr22. Doklady Akademii Nauk 372(3): 401-403, 2000

Expression analysis of endogenous retroviral elements belonging to the HERV-F family from human tissues and cancer cells. Cancer Letters 211(1): 89-96, 2004

Molecular genetic analyses of human endogenous retroviral elements belonging to the HERV-P family in primates, human tissues, and cancer cells. Genomics 89(1): 1-9, 2006

Human endogenous retroviral elements belonging to the HERV-S family from human tissues, cancer cells, and primates: expression, structure, phylogeny and evolution. Gene 342(2): 283-292, 2004

Proviral structure, chromosomal distribution and expression of HERV-K A novel human endogenous retroviral element of the HERV-K superfamily derived from T47D cells and particles. Journal of Molecular Medicine (Berlin) 75(7): B226-B227, 1997

Cloning and phylogeny of endogenous retroviral elements belonging to the HERV-K LTR in cDNA library of human fetal brain and Xq21.3 region linked to psychosis. Korean Journal of Genetics 23(2): 129-134, June, 2001

Human endogenous retroviral elements promote genome instability via non-allelic homologous recombination. Bmc Biology 12(): 74-74, 2015

Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis. Journal of Neuroimmunology 249(1-2): 105-108, 2012

Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3. Journal of Virology 85(7): 3436-3448, 2011

Spliced human endogenous retroviral HERV-H env transcripts in T-cell leukaemia cell lines and normal leukocytes: alternative splicing pattern of HERV-H transcripts. Journal of General Virology 78: 2575-2585, 1998

A human endogenous retrovirus-like (HERV) LTR formed more than 10 million years ago due to an insertion of HERV-H LTR into the 5' LTR of HERV-K is situated on human chromosomes 10, 19 and Y. Journal of General Virology 80: 835-839, 1999

Expression of human endogenous retroviral sequence HERV-K in non-Hodgkin lymphomas. Annals of Hematology 67(SUPPL ): A91, 1993

Identification of novel human endogenous retroviral sequences belonging to the HERV-K family. Aids Research and Human Retroviruses 14(12): 1093-1098, 1998