Section 12
Chapter 11,744

Alternatively spliced transcripts of Fas mRNAs in feline lymphoid cells

Mizuno, T.; Baba, K.; Goto, Y.; Masuda, K.; Ohno, K.; Tsujimoto, H.

European Journal of Immunogenetics Official Journal of the British Society for Histocompatibility and Immunogenetics 31(4): 159-166


ISSN/ISBN: 0960-7420
PMID: 15265020
DOI: 10.1111/j.1365-2370.2004.00463.x
Accession: 011743728

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Fas belongs to the tumour necrosis factor receptor family and transduces the death signal after binding to the Fas ligand. Five feline lymphoma cell lines were shown, by reverse transcription-polymerase chain reaction, to express six species of Fas transcripts. Based on sequence comparison of these Fas transcripts with the genomic Fas gene, five of the six transcripts were found to be generated through alternative splicing and to encode five different Fas proteins lacking the transmembrane domain. We also detected such alternatively spliced transcripts in primary tumour tissues from cats with naturally occurring lymphoma. These results suggest a possible association of the alternatively spliced Fas variants with the pathogenesis of feline lymphoma.

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