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An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer



An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer



Breast Cancer Research and Treatment 99(3): 257-265



XRCC1 coordinates the activities of DNA polymerasc-beta and DNA ligase for base excision repair of oxidative DNA damage. In addition, there is some evidence that XRCC1 is a negative regulator of apoptosis. Single nucleotide polymorphisms in XRCC1 have been inconsistently associated with breast cancer risk. We evaluated XRCC1 gene expression in breast cancer cell lines and carcinogen-induced apoptosis in benign breast epithelial cells in relation to XRCC1 genotypes.

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Accession: 011752176

Download citation: RISBibTeXText

PMID: 16596326

DOI: 10.1007/s10549-006-9210-3



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