EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits



Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits



Journal of Clinical Endocrinology and Metabolism 90(5): 2988-2993



Context: Variation at the insulin gene VNTR ( variable number tandem repeat) minisatellite has been reported to be associated with polycystic ovary syndrome ( PCOS), but findings have been inconsistent and all studies have featured small sample sizes.Objective: To gain a robust understanding of the role of the INS-VNTR in PCOS susceptibility.Design: Case-control, family-based association and quantitative trait analyses.Setting and Participants: A UK population comprising 255 parent-offspring trios, 185 additional cases, and 1062 control subjects ( cases and controls all British/Irish) as well as 1599 women from a northern Finland population-based birth cohort characterized for PCO symptomatology and testosterone levels. VNTR class was inferred from genotyping of the - 23HphI variant.Intervention(s): None.Main Outcome Measure(s): INS-VNTR genotype frequencies between subject groups, body mass index, and testosterone levels by genotype.Results: Case-control analyses in both UK and Finnish samples failed to confirm previously reported class III allele associations with PCOS( UK, P = 0.43, Finnish, P = 0.31; Kruskal-Wallis chi(2)). Transmission analysis in trios showed no excess transmission of either allele ( P = 0.62), regardless of parent of origin ( maternal: P = 0.73; paternal: P = 0.66). No association between genotype and testosterone levels was seen in any sample ( UK PCOS subjects, P = 0.95; Finnish symptomatic cases, P = 0.38; Finnish control women, P = 0.58).Conclusions: Despite the strong biological candidacy and supportive data from previous studies, we conclude that variation at the INS-VNTR has no major role in the development of PCOS.

(PDF emailed within 0-6 h: $19.90)

Accession: 011757131

Download citation: RISBibTeXText

PMID: 15705917

DOI: 10.1210/jc.2004-2485



Related references

Association of insulin gene variable number of tandem repeats regulatory polymorphism with polycystic ovary syndrome. Human Immunology 75(10): 1047-1052, 2015

Assessment of the application of variable-number tandem repeat loci of Salmonella Enteritidis in subtyping multiple-locus variable-number tandem repeat analysis. Zhonghua Yu Fang Yi Xue Za Zhi 45(6): 516-521, 2012

Molecular surveillance of methicillin-resistant Staphylococcus aureus by multiple-locus variable number tandem repeat fingerprinting (formerly multiple-locus variable number tandem repeat analysis) and spa typing in a hierarchic approach. Diagnostic Microbiology and Infectious Disease 62(3): 255-262, 2008

Molecular surveillance of methicillin-resistant Staphylococcus aureus by multiple-locus variable number tandem repeat fingerprinting (formerly multiple-locus variable number tandem repeat analysis) and spa. 2008

Multiple-locus variable-number tandem repeat analysis reveals genetic relationships within Bacillus anthracis. Journal of Bacteriology 182(10): 2928-2936, 2000

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles. Diabetes 49(1): 126-130, 2000

A new multiple-locus variable-number tandem repeat analysis reveals different clusters for Anaplasma phagocytophilum circulating in domestic and wild ruminants. Parasites & Vectors 7(): 439-439, 2015

Multiple-locus variable-number tandem repeat analysis (MLVA) of Leptospira interrogans serovar Pomona from Argentina reveals four new genotypes. Comparative Immunology, Microbiology and Infectious Diseases 31(1): 37-45, 2007

Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s. Journal of Bacteriology 186(16): 5496-5505, 2004

Multiple-locus variable-number tandem repeat analysis potentially reveals the existence of two groups of Anaplasma phagocytophilum circulating in cattle in France with different wild reservoirs. Parasites & Vectors 9(1): 596-596, 2016

Multi-locus variable-number tandem repeat analysis (MLVA) reveals heterogeneity of Mycobacterium bovis strains and multiple genotype infections of cattle in Ethiopia. Infection, Genetics and Evolution 23: 13-19, 2014

Family-based association study of a variable number of tandem repeat polymorphism of DAT1 gene with Tourette syndrome in a Chinese Han population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30(5): 594-597, 2014

Differential gene expression in granulosa cells from polycystic ovary syndrome patients with and without insulin resistance: identification of susceptibility gene sets through network analysis. Journal of Clinical Endocrinology and Metabolism 97(10): E2016-E2021, 2012

Multilocus Variable Number of Tandem Repeat Analysis Reveals Multiple Introductions in Spain of Xanthomonas arboricola pv. pruni, the Causal Agent of Bacterial Spot Disease of Stone Fruits and Almond. Plos One 11(9): E0163729-E0163729, 2016