+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibacterial therapy of urogenital mycoplasma infections. Comparative study of wilprafen and doxycycline efficiency

Antibacterial therapy of urogenital mycoplasma infections. Comparative study of wilprafen and doxycycline efficiency

Vestnik Dermatologii i Venerologii (6): 41-43

This study was made to compare therapeutic efficiency of wilprafen (16-membered macrolid antibiotic) and doxycycline in patients with urogenital inflammation caused by mycoplasma infection. The randomized study involved 56 patients (17 men and 39 women, mean age 28 years) with urethritis and cervicitis associated with U. uralyticum or M. hominis infection. The infection was diagnosed by polymerase chain reaction (PCR) using epithelial scrapes from the cervical canal of the uterus and/or urethra. The patients were randomly allocated to two groups. Patients of group 1 (n=29) received wilprafen (500 mg twice daily for 12 days), those in group 2 (n=27) were given doxycycline (100 mg twice daily for 10 days). After a follow-up of 4 weeks, all patients were examined to identify changes in the clinical course of the disease and the presence of infection (repeat PCR). The therapy resulted in the improvement of clinical features in the majority of patients. They persisted in four of them receiving doxycycline and in one receiving wilprafen. Wilprafen therapy resulted in the eradication of infection in 26 of 27 patients, doxycycline produced a similar effect in 21 of 29 patients (p=0.017). Wilprafen therapy was better tolerated by the patients (p=0.033). It is concluded that wilprafen is a more efficient drug for the treatment of urogenital mycoplasma infection than traditional doxycycline therapy.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 011765978

Download citation: RISBibTeXText

Related references

The use of wilprafen (josamycin) for the treatment of mixed urogenital Chlamydia-Mycoplasma infection in women of reproductive age. Vestnik Dermatologii i Venerologii (3): 69-72, 2004

Ciprofloxacin versus doxycycline in the treatment of uncomplicated urogenital Chlamydia trachomatis infections. A double-blind comparative study. Scandinavian Journal of Infectious Diseases. Supplementum 60: 62-65, 1989

Urogenital mycoplasmal infections: Comparative evaluation of test kits Mycoplasma IST, Mycoplasma-Kit and ATB mycoplasmas used in isolation, identification, titration and antibiogram. Feuillets de Biologie 35(201): 35-40, 1994

Comparative studies of doxycycline and tetracyclines in the treatment of urogenital tract infections. Medizinische Klinik 67(36): 1141-1144, 1972

Wilprafen (josamycin) therapy of patients with urogenital inflammations. Urologiia: 23-24, 2001

Isolation of human urogenital mycoplasma, Mycoplasma hominis and Ureaplasma urealyticum--comparative study between Mycotrim-GU and conventional culture methods. Kansenshogaku Zasshi. Journal of the Japanese Association for Infectious Diseases 62(1): 49-54, 1988

A randomized, comparative study of dual therapy (doxycycline-rifampin) versus triple therapy (doxycycline-rifampin-levofloxacin) for treating acute/subacute brucellosis. Brazilian Journal of Infectious Diseases 20(3): 250-254, 2016

Urogenital mycoplasma infections of man: a review with observations on a recently discovered mycoplasma. Israel Journal of Medical Sciences 17(7): 524-530, 1981

Effect of combined therapy using complex of natural cytokines and antimicrobial peptides in urogenital infections caused by Chlamydia and Mycoplasma. Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii (): 90-93, 2011

Comparative study of Mycoplasma pulmonis and Mycoplasma gallisepticum infections in turkey sinus. American Journal of Veterinary Research 36(9): 1401-1402, 1975

A comparative study of three different PCR assays for detection of Mycoplasma genitalium in urogenital specimens from men and women. Journal of Medical Microbiology 57(Pt 3): 304-309, 2008

Urogenital chlamydia infection: treatment with wilprafen. Urologiia: 55-58, 2003

A multicenter comparative study of cefepime versus broad-spectrum antibacterial therapy in moderate and severe bacterial infections. Brazilian Journal of Infectious Diseases 6(5): 206-218, 2002

Urogenital Chlamydial infection: Etiotropic treatment with wilprafen. Urologiya (Moscow) (1): 55-58, January-February, 2003

Clinical studies on doxycycline treatment of urogenital Chlamydia trachomatis infections. Japanese Journal of Antibiotics 39(1): 17-23, 1986