Section 12
Chapter 11,769

Antileukemic effect of interleukin-7-transduced bone marrow stromal cells in mice following allogeneic T-cell-depleted bone marrow transplantation

Li, A.L.; Li, C.; Feng, Y.G.; Yuan, G.H.; Wang, G.M.; Hao, J.; Gao, X.; Xie, S.S.

Transplantation Proceedings 37(5): 2297-2299


ISSN/ISBN: 0041-1345
PMID: 15964403
DOI: 10.1016/j.transproceed.2005.03.088
Accession: 011768173

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Impaired immune reconstitution following allogeneic bone marrow transplantation (BMT) remains a major obstacle to its clinical application. In this study, interleukin (IL)-7-transduced bone marrow stromal cells (MSC-IL7, 1 X 10(6)/mouse) were transfused into lethally irradiated C57BL/6 recipient mice. By day 40 after transplantation, the recipient mice were challenged with the lymphoma cell line EL4. MSC-IL7 cotransplantation protected recipient mice from leukemic mortality (MST > 120 days after BMT vs mean survival time (MST) 70 days in the PBS group) It enhance the PFC count and DTH responses of recipients after transplantation.

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