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Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein

Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein

Journal of Physiology 567(Pt 3): 787-798

In many non-excitable cells, the predominant mode of agonist-activated Ca2+ entry switches from the arachidonic acid-regulated Ca2+ (ARC) channels at low agonist concentrations, to store-operated channels at high concentrations. Underlying this process is the inhibition of the ARC channels by a calcineurin-mediated dephosphorylation, which inhibits the ability of arachidonic acid to activate the channels.

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Accession: 011776964

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PMID: 15994185

DOI: 10.1113/jphysiol.2005.090209

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