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Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene

Fisher, D.J.; Miyamoto, K.; Harrison, B.; Akimoto, S.; Sarker, M.R.; McClane, B.A.

Molecular Microbiology 56(3): 747-762

2005


ISSN/ISBN: 0950-382X
PMID: 15819629
DOI: 10.1111/j.1365-2958.2005.04573.x
Accession: 011786444

Clostridium perfringens type A isolates carrying an enterotoxin (cpe) gene are an important cause of human gastrointestinal diseases, including food poisoning, antibiotic-associated diarrhoea (AAD) and sporadic diarrhoea (SD). Using polymerase chain reaction (PCR), the current study determined that the cpb2 gene encoding the recently discovered beta2 toxin is present in < 15% of food poisoning isolates, which typically carry a chromosomal cpe gene.

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